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Bisrat G. Debeb
Researcher at University of Texas MD Anderson Cancer Center
Publications - 66
Citations - 2472
Bisrat G. Debeb is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Inflammatory breast cancer & Breast cancer. The author has an hindex of 25, co-authored 60 publications receiving 2062 citations. Previous affiliations of Bisrat G. Debeb include Texas A&M University & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1
Peijing Zhang,Yongkun Wei,Linghua Wang,Bisrat G. Debeb,Yuan Yuan,Jinsong Zhang,Jingsong Yuan,Min Wang,Dahu Chen,Yutong Sun,Wendy A. Woodward,Yongqing Liu,Douglas C. Dean,Han Liang,Ye Hu,K. Kian Ang,Mien Chie Hung,Junjie Chen,Li Ma +18 more
TL;DR: ZEB1 is identified as an ATM substrate linking ATM to CHK1 and the mechanism underlying the association between EMT and radioresistance, which promotes homologous recombination-dependent DNA repair and resistance to radiation.
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Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells
Ann H. Klopp,Lara Lacerda,Lara Lacerda,Lara Lacerda,Anshul Gupta,Bisrat G. Debeb,Travis Solley,Li Li,Erika L. Spaeth,Wei Xu,Xiaomei Zhang,Michael T. Lewis,James M. Reuben,Savitri Krishnamurthy,Mauro Ferrari,Rogério Gaspar,Thomas A. Buchholz,Massimo Cristofanilli,Frank C. Marini,Michael Andreeff,Wendy A. Woodward +20 more
TL;DR: MSC increase the efficiency of primary mammosphere formation in normal and malignant breast cells and decrease E-cadherin expression, a biologic event associated with breast cancer progression and resistance to therapy.
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Omental Adipose Tissue–Derived Stromal Cells Promote Vascularization and Growth of Endometrial Tumors
Ann H. Klopp,Yan Zhang,Travis Solley,Felipe Amaya-Manzanares,Frank C. Marini,Frank C. Marini,Michael Andreeff,Bisrat G. Debeb,Wendy A. Woodward,Rosemarie Schmandt,Russell Broaddus,Karen H. Lu,Mikhail G. Kolonin +12 more
TL;DR: It is proposed that O-ASCs recruited to tumors express specific factors that enhance tumor vascularization, promoting survival and proliferation of tumor cells, and that Visceral adipose tissue contains a population of multipotent MSCs that promote endometrial tumor growth more potently than M SCs from subcutaneous adiposes tissue.
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miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13
Peijing Zhang,Li Wang,Cristian Rodriguez-Aguayo,Yuan Yuan,Bisrat G. Debeb,Dahu Chen,Yutong Sun,M. James You,Yongqing Liu,Douglas C. Dean,Wendy A. Woodward,Han Liang,Xianbin Yang,Gabriel Lopez-Berestein,Anil K. Sood,Ye Hu,K. Kian Ang,Junjie Chen,Li Ma +18 more
TL;DR: It is found that miR-205 promotes radiosensitivity and is downregulated in radioresistant subpopulations of breast cancer cells, and that loss of miR -205 is highly associated with poor distant relapse-free survival in breast cancer patients.
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Inflammatory breast cancer: a model for investigating cluster-based dissemination
Mohit Kumar Jolly,Marcelo Boareto,Bisrat G. Debeb,Nicola Aceto,Mary C. Farach-Carson,Mary C. Farach-Carson,Wendy A. Woodward,Herbert Levine +7 more
TL;DR: The highly aggressive Inflammatory Breast Cancer is discussed as an example of a carcinoma that can metastasize via clusters and a possible mechanistic understanding of why clusters are endowed with higher metastatic potential is offered.