K
Kristina Anderson
Researcher at Lund University
Publications - 23
Citations - 4319
Kristina Anderson is an academic researcher from Lund University. The author has contributed to research in topics: Progenitor cell & Stem cell. The author has an hindex of 18, co-authored 23 publications receiving 4023 citations. Previous affiliations of Kristina Anderson include Karolinska Institutet & Oslo University Hospital.
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Journal ArticleDOI
Identification of Flt3(+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment
Jörgen Adolfsson,Robert Månsson,Natalija Buza-Vidas,Anne Hultquist,Karina Liuba,Christina Jensen,David Bryder,Liping Yang,O J Borge,Lina Thorén,Kristina Anderson,Ewa Sitnicka,Yutaka Sasaki,Mikael Sigvardsson,Sten Eirik W. Jacobsen +14 more
TL;DR: Evidence is presented for a population of cells which, although sustaining a high proliferative and combined lympho-myeloid differentiation potential, have lost the ability to adopt erythroid and megakaryocyte lineage fates.
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Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
TL;DR: Activation of canonical Wnt signaling through conditional expression of a stable form of β-catenin causes multilineage differentiation block and compromised hematopoietic stem cell maintenance.
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Molecular Evidence for Hierarchical Transcriptional Lineage Priming in Fetal and Adult Stem Cells and Multipotent Progenitors
Robert Månsson,Anne Hultquist,Sidinh Luc,Liping Yang,Kristina Anderson,Shabnam Kharazi,Suleiman Al-Hashmi,Karina Liuba,Lina Thorén,Jörgen Adolfsson,Natalija Buza-Vidas,Hong Qian,Shamit Soneji,Tariq Enver,Mikael Sigvardsson,Sten Eirik W. Jacobsen +15 more
TL;DR: Global and single-cell analyses revealed a hierarchical organization of transcriptional lineage programs, with downregulation of megakaryocyte-erythroid genes from HSCs to LMPPs, sustained granulocyte-monocyte priming, and upregulation of common lymphoid (but not B and T cell-specific) genes.
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Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia
Anders Castor,Lennart Nilsson,Ingbritt Åstrand-Grundström,Miranda Buitenhuis,Carole Ramirez,Kristina Anderson,Bodil Strömbeck,Stanislaw Garwicz,Albert N. Békássy,Kjeld Schmiegelow,Birgitte Lausen,Peter Hokland,Sören Lehmann,Gunnar Juliusson,Bertil Johansson,Sten Eirik W. Jacobsen +15 more
TL;DR: It is shown that clinically and genetically different subtypes of acute lymphoblastic leukemia (ALL) originate and transform at distinct stages of hematopoietic development.
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Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Alice Giustacchini,Supat Thongjuea,Nikolaos Barkas,Petter S. Woll,Benjamin J. Povinelli,Christopher A.G. Booth,Paul Sopp,Ruggiero Norfo,Alba Rodriguez-Meira,Neil Ashley,Lauren Jamieson,Paresh Vyas,Kristina Anderson,Åsa Segerstolpe,Hong Qian,Ulla Olsson-Strömberg,Satu Mustjoki,Rickard Sandberg,Rickard Sandberg,Sten Eirik W. Jacobsen,Adam J. Mead,Adam J. Mead +21 more
TL;DR: A method that combines high-sensitivity mutation detection with whole-transcriptome analysis of the same single cell is developed, illustrating how single-cell analysis can identify subpopulations of therapy-resistant SCs that are not apparent through cell-population analysis.