M
Marsha Speevak
Researcher at HealthPartners
Publications - 30
Citations - 958
Marsha Speevak is an academic researcher from HealthPartners. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 14, co-authored 29 publications receiving 746 citations. Previous affiliations of Marsha Speevak include University of Toronto & Credit Valley Hospital.
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Journal ArticleDOI
Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes
Anath C. Lionel,Kristiina Tammimies,Kristiina Tammimies,Andrea K. Vaags,Jill A. Rosenfeld,Joo Wook Ahn,Daniele Merico,Abdul Noor,Cassandra K. Runke,Vamsee Pillalamarri,Melissa T. Carter,Matthew J. Gazzellone,Bhooma Thiruvahindrapuram,Christina Fagerberg,Lone W. Laulund,Giovanna Pellecchia,Sylvia Lamoureux,Charu Deshpande,Jill Clayton-Smith,Ann C White,Susan Leather,John Trounce,H. Melanie Bedford,Eli Hatchwell,Peggy S. Eis,Ryan K. C. Yuen,Susan Walker,Mohammed Uddin,Michael T. Geraghty,Michael T. Geraghty,Sarah M. Nikkel,Sarah M. Nikkel,Eva M Tomiak,Bridget A. Fernandez,Noam Soreni,Jennifer Crosbie,Paul D. Arnold,Russell Schachar,Wendy Roberts,Andrew D. Paterson,Joyce So,Peter Szatmari,Christina Chrysler,Marc Woodbury-Smith,R. Brian Lowry,Lonnie Zwaigenbaum,Divya Mandyam,John Wei,Jeffrey R. MacDonald,Jennifer L. Howe,Thomas Nalpathamkalam,Zhuozhi Wang,Daniel Tolson,David S Cobb,Timothy Wilks,Mark J Sorensen,Patricia I. Bader,Yu An,Bai-Lin Wu,Bai-Lin Wu,Bai-Lin Wu,Sebastiano A. Musumeci,Corrado Romano,Diana Postorivo,Anna Maria Nardone,Matteo Della Monica,Gioacchino Scarano,Leonardo Zoccante,Francesca Novara,Orsetta Zuffardi,Roberto Ciccone,Vincenzo Antona,Massimo Carella,Leopoldo Zelante,Pietro Cavalli,Carlo Poggiani,Ugo Cavallari,Bob Argiropoulos,Bob Argiropoulos,Bob Argiropoulos,Judy Chernos,Judy Chernos,Judy Chernos,Charlotte Brasch-Andersen,Marsha Speevak,Marco Fichera,Caroline Mackie Ogilvie,Yiping Shen,Yiping Shen,Yiping Shen,Jennelle C. Hodge,Michael E. Talkowski,Dimitri J. Stavropoulos,Christian R. Marshall,Stephen W. Scherer +94 more
TL;DR: The 3'-terminal ASTN2 deletions were significantly enriched compared with controls in males with NDDs, but not in females, and new light is shed on the role of the astrotactins in psychopathology and their interplay in human neurodevelopment.
Journal ArticleDOI
Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays
Gregory Costain,Anath C. Lionel,Anath C. Lionel,Daniele Merico,Pamela Forsythe,Kathryn Russell,Chelsea Lowther,Tracy Yuen,Janice A. Husted,Dimitri J. Stavropoulos,Marsha Speevak,Eva W.C. Chow,Eva W.C. Chow,Christian R. Marshall,Christian R. Marshall,Stephen W. Scherer,Stephen W. Scherer,Anne S. Bassett,Anne S. Bassett +18 more
TL;DR: Consideration of a potential role for clinical microarray testing in schizophrenia, as is now the suggested standard of care for related developmental disorders like autism, is suggested.
Journal ArticleDOI
A large data resource of genomic copy number variation across neurodevelopmental disorders.
Mehdi Zarrei,Christie L. Burton,Worrawat Engchuan,Young Ej,Edward J Higginbotham,Edward J Higginbotham,MacDonald,Brett Trost,Chan Ajs,Chan Ajs,Susan Walker,Sylvia Lamoureux,Heung T,Bahareh A. Mojarad,Barbara Kellam,Tara Paton,Muhammad Faheem,Miron K,Lu C,Wang T,Kozue Samler,Wang X,Gregory A. Costain,Ny Hoang,Giovanna Pellecchia,John Wei,Rohan V. Patel,Bhooma Thiruvahindrapuram,Maian Roifman,Maian Roifman,Daniele Merico,Tara Goodale,Drmic I,Marsha Speevak,Jennifer L. Howe,Yuen Rkc,Janet A. Buchanan,Vorstman Jas,Christian R. Marshall,Christian R. Marshall,Richard F. Wintle,David R. Rosenberg,Gregory L. Hanna,Marc Woodbury-Smith,Marc Woodbury-Smith,Cheryl Cytrynbaum,Lonnie Zwaigenbaum,Mayada Elsabbagh,Flanagan J,Bridget A. Fernandez,Melissa T. Carter,Peter Szatmari,Peter Szatmari,Wendy Roberts,Jason P. Lerch,Xudong Liu,Rob Nicolson,Stelios Georgiades,Rosanna Weksberg,Paul D. Arnold,Paul D. Arnold,Anne S. Bassett,Anne S. Bassett,Anne S. Bassett,Jennifer Crosbie,Russell Schachar,Dimitri J. Stavropoulos,Evdokia Anagnostou,Stephen W. Scherer +68 more
TL;DR: This is the first genome-wide CNV analysis across autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia, and obsessive-compulsive disorder at once, and it is demonstrated that CNVs impacting the same genes could potentially contribute to the etiology of multiple NDDs.
Journal ArticleDOI
OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome
Mohammed Uddin,Mohammed Uddin,Brianna K. Unda,Vickie Kwan,Nicholas Holzapfel,Sean H. White,Leon Chalil,Marc Woodbury-Smith,Marc Woodbury-Smith,Karen S. Ho,Erin Harward,Nadeem Murtaza,Biren M. Dave,Giovanna Pellecchia,Lia D’Abate,Lia D’Abate,Thomas Nalpathamkalam,Sylvia Lamoureux,John Wei,Marsha Speevak,James Stavropoulos,Kristin J Hope,Brad Doble,Jacob Nielsen,E. Robert Wassman,Stephen W. Scherer,Stephen W. Scherer,Karun K. Singh +27 more
TL;DR: Analysis of large-scale genomic, transcriptomic, and proteomic data identified OTUD7A as a critical gene for brain function and its reduced levels in Df(h15q13)/+ cortical neurons contributed to the dendritic spine and dendrite outgrowth deficits.
Journal ArticleDOI
Molecular characterization of NRXN1 deletions from 19,263 clinical microarray cases identifies exons important for neurodevelopmental disease expression
Chelsea Lowther,Marsha Speevak,Christine M. Armour,Elaine Suk-Ying Goh,Gail E. Graham,Chumei Li,Chumei Li,Susan Zeesman,Małgorzata J.M. Nowaczyk,Małgorzata J.M. Nowaczyk,Lee-Anne Schultz,Antonella Morra,Rob Nicolson,Peter Bikangaga,Dawa Samdup,Mostafa Zaazou,Kerry Boyd,Jack H. Jung,Victoria Mok Siu,Manjulata Rajguru,Sharan Goobie,Mark A. Tarnopolsky,Chitra Prasad,Paul T. Dick,Asmaa S. Hussain,Margreet Walinga,Renske G. Reijenga,Matthew J. Gazzellone,Anath C. Lionel,Christian R. Marshall,Stephen W. Scherer,Stephen W. Scherer,Dimitri J. Stavropoulos,Elizabeth McCready,Anne S. Bassett +34 more
TL;DR: The results support the importance of exons near the 5ʹ end of NRXN1 in the expression of neurodevelopmental disorders and suggest that intronic NRxN1 deletions do not appear to substantially increase the risk for clinical phenotypes.