Bojana Jakic

TL;DR: All healthy humans develop cellular and humoral immunity against microbial HSP60 by infection or vaccination, but atherosclerosis might be the price the authors pay for this protective immunity, if risk factors stress the vascular endothelial cells beyond physiological conditions.

TL;DR: It is shown that nuclear receptor NR2F6 acts as an immune checkpoint in T cells and, using mouse models and human T cells, it is shown NR2f6 inhibition might improve current ICB therapy or work as an alternative therapeutic strategy.

TL;DR: It is shown that increasing levels of sodium chloride can also induce an increase in intracellular and surface expression of HSP60 protein in human umbilical vein endothelial cells, and it is found that elevated sodium induces apoptosis.

TL;DR: Atheroprotective mbHSP65 peptides may be considered as potential candidates for the development of a tolerizing vaccine to prevent and treat atherosclerosis, while keeping protective immunity to non-atherogenic domains of mb HSP65 intact.

TL;DR: It is shown that FcμR is mostly stored inside the cell and that surface expression is tightly regulated, and that decreased surface expression on T cells from elderly individuals is associated with alterations in the methylation pattern of the FCMR gene.