M
Mikko Hurme
Researcher at University of Tampere
Publications - 298
Citations - 13124
Mikko Hurme is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genotype. The author has an hindex of 60, co-authored 289 publications receiving 11862 citations. Previous affiliations of Mikko Hurme include University of Jyväskylä & University of Turku.
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Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1beta production in vitro.
TL;DR: The data suggest that the known allelisms in the IL‐1β gene are not major regulators of the in vitro IL‐ 1β production, but theIL‐1RA allele 2 (or an unknown allele strongly associated with it) has a decisive role.
Journal ArticleDOI
Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG.
TL;DR: Oral Lactobacillus rhamnosus GG ingestion for 5’days to 4’weeks has been shown to alleviate clinical symptoms of gastrointestinal inflammation and atopic dermatitis.
Journal ArticleDOI
IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes.
Mikko Hurme,Sari Santtila +1 more
TL;DR: The results indicate that theIL‐1β gene participates in the regulation of IL‐1Ra production in vivo and that the alleles of IL-1β and IL‐ 1Ra which demonstrate this cooperative effect are often associated.
Journal ArticleDOI
Mitochondrial DNA polymorphisms associated with longevity in a Finnish population.
TL;DR: The data appear to favour the presence of advantageous polymorphisms and support a role for mitochondria and mtDNA in the degenerative processes involved in ageing and suggest an association between certain mtDNA haplogroups or haplogroup clusters and longevity.
Journal ArticleDOI
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Joris Deelen,Joris Deelen,Daniel S. Evans,Dan E. Arking,Niccolò Tesi,Niccolò Tesi,Marianne Nygaard,Xiaomin Liu,Mary K. Wojczynski,Mary L. Biggs,Ashley van der Spek,Gil Atzmon,Gil Atzmon,Erin B. Ware,Chloé Sarnowski,Albert V. Smith,Ilkka Seppälä,Heather J. Cordell,Janina Dose,Najaf Amin,Alice M. Arnold,Kristin L. Ayers,Nir Barzilai,Elizabeth J. Becker,Marian Beekman,Hélène Blanché,Kaare Christensen,Lene Christiansen,Lene Christiansen,J. Collerton,Sarah Cubaynes,Steven R. Cummings,Karen Davies,Birgit Debrabant,Jean-François Deleuze,Rachel Duncan,Jessica D. Faul,Claudio Franceschi,Pilar Galan,Vilmundur Gudnason,Tamara B. Harris,Martijn Huisman,Martijn Huisman,Mikko Hurme,Carol Jagger,Iris E. Jansen,Marja Jylhä,Mika Kähönen,David Karasik,David Karasik,Sharon L.R. Kardia,Andrew Kingston,Thomas B. L. Kirkwood,Lenore J. Launer,Terho Lehtimäki,Wolfgang Lieb,Leo-Pekka Lyytikäinen,Carmen Martin-Ruiz,Junxia Min,Almut Nebel,Anne B. Newman,Chao Nie,Ellen A. Nohr,Eric S. Orwoll,Thomas T. Perls,Michael A. Province,Bruce M. Psaty,Bruce M. Psaty,Olli T. Raitakari,Marcel J. T. Reinders,Jean-Marie Robine,Jerome I. Rotter,Paola Sebastiani,Jennifer A. Smith,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Kent D. Taylor,André G. Uitterlinden,Wiesje M. van der Flier,Sven J. van der Lee,Cornelia M. van Duijn,Cornelia M. van Duijn,Diana van Heemst,James W. Vaupel,David R. Weir,Kenny Ye,Yi Zeng,Yi Zeng,Wanlin Zheng,Henne Holstege,Henne Holstege,Douglas P. Kiel,Douglas P. Kiel,Kathryn L. Lunetta,P. Eline Slagboom,Joanne M. Murabito,Joanne M. Murabito +96 more
TL;DR: A case–control design based on phenotype definitions of individuals surviving at or beyond the age corresponding to the 90th and 99th survival percentile, and two additional loci located in the APOE locus and near GPR78 are reported, revealing a role for tissue-specific expression of multiple genes in longevity.