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Boldizsár Czéh

Researcher at University of Pécs

Publications -  82
Citations -  7985

Boldizsár Czéh is an academic researcher from University of Pécs. The author has contributed to research in topics: Dentate gyrus & Hippocampal formation. The author has an hindex of 36, co-authored 76 publications receiving 7226 citations. Previous affiliations of Boldizsár Czéh include Aarhus University & German Primate Center.

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Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine

TL;DR: The effect of tianeptine, a modified tricyclic antidepressant, in the chronic psychosocial stress model of adult male tree shrews, a model with high validity for research on the pathophysiology of major depression, is investigated.
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Hippocampal network patterns of activity in the mouse

TL;DR: The electrical patterns in the behaving animal are investigated using multisite silicon probes and wire tetrodes and it is suggested that the main hippocampal network patterns are mediated by similar pathways and mechanisms in mouse and rat.
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Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys.

TL;DR: Prenatal stress resulted in a reduced hippocampal volume and an inhibition of neurogenesis in the dentate gyrus, which indicates that the prenatal environment can alter behavior, dysregulate neuroendocrine systems, and affect the hippocampal structure of primates in a persistent manner.
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Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action

TL;DR: It is concluded that a lasting reduction in neurogenesis following severe or chronic stress exposure, either in adult or early life, may represent impaired hippocampal plasticity and can contribute to the cognitive symptoms of depression, but is, by itself, unlikely to produce the full mood disorder.
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What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?

TL;DR: Other factors, like alterations in the somatodendritic, axonal, and synaptic components and putative glial changes are most likely to explain the hippocampal shrinkage in depression, while shifts in fluid balance or changes in the extracellular space cannot be excluded.