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Bradley Dean Tait
Researcher at Parke-Davis
Publications - 31
Citations - 1351
Bradley Dean Tait is an academic researcher from Parke-Davis. The author has contributed to research in topics: Protease & HIV Protease Inhibitor. The author has an hindex of 14, co-authored 31 publications receiving 1325 citations. Previous affiliations of Bradley Dean Tait include Louisiana State University.
Papers
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Journal ArticleDOI
A rapid screening test to determine the antioxidant potencies of natural and synthetic antioxidants
William A. Pryor,Joseph A. Cornicelli,L. J. Devall,Bradley Dean Tait,B. K. Trivedi,D. T. Witiak,Mingdan Wu +6 more
TL;DR: In this article, a simple and convenient method for measuring antioxidant efficiencies in a model system consisting of micelles of sodium dodecyl sulfate (SDS) with added linoleic acid was presented.
Journal ArticleDOI
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties
Sandra M. Sendobry,Joseph A. Cornicelli,Kathryn Welch,Thomas M.A. Bocan,Bradley Dean Tait,Bharat K. Trivedi,Norman L. Colbry,Richard D. Dyer,Steven J. Feinmark,Alan Daugherty +9 more
TL;DR: Results are consistent with a role for 15‐LO in atherogenesis and plasma concentrations achieved in vivo did not inhibit low‐density lipoprotein (LDL) oxidation in vitro.
Patent
Method for treating and preventing inflammation and atherosclerosis
TL;DR: In this article, a method for treating or preventing inflammation or atherosclerosis in mammals comprising administering an effective amount of a 15-LO inhibitor of Formula I was proposed. But this method is not suitable for humans.
Journal ArticleDOI
Novel Series of Achiral, Low Molecular Weight, and Potent HIV-1 Protease Inhibitors
J. V. N. Vara Prasad,Kimberly Suzanne Para,Elizabeth A. Lunney,Daniel F. Ortwine,James B. Dunbar,Donna Ferguson,Peter J. Tummino,Donald Hupe,Bradley Dean Tait +8 more
Journal ArticleDOI
A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs
Elizabeth A. Lunney,Susan Elizabeth Hagen,John M. Domagala,Christine Humblet,Janet Kosinski,Bradley Dean Tait,Joseph S. Warmus,Michael D. Wilson,Donna Ferguson +8 more
TL;DR: Using an HIV-1 protease mass screening technique, 4-hydroxy-3-(3-phenoxypropyl)-2H-1-benzopyran-2-one was identified as a nonpeptide competitive inhibitor of the enzyme.