H
Han Dai
Researcher at GlaxoSmithKline
Publications - 31
Citations - 3516
Han Dai is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Synaptotagmin 1 & Complexin. The author has an hindex of 19, co-authored 31 publications receiving 3009 citations. Previous affiliations of Han Dai include University of Texas Southwestern Medical Center & Nanjing University.
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Journal ArticleDOI
Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
Basil P. Hubbard,Ana P. Gomes,Ana P. Gomes,Han Dai,Jun Li,April Case,Thomas Considine,Thomas V. Riera,Jessica E. Lee,Sook Yen E,Dudley W. Lamming,Bradley L. Pentelute,Eli Schuman,Linda A. Stevens,Alvin J. Y. Ling,Sean M. Armour,Shaday Michan,Huizhen Zhao,Yong Jiang,Sharon Sweitzer,Charles A. Blum,Jeremy S. Disch,Pui Yee Ng,Konrad T. Howitz,Anabela P. Rolo,Anabela P. Rolo,Yoshitomo Hamuro,Joel Moss,Robert B. Perni,James L. Ellis,George P. Vlasuk,David A. Sinclair,David A. Sinclair +32 more
TL;DR: SIRT1 can be directly activated through an allosteric mechanism common to chemically diverse STACs, and specific hydrophobic motifs found in SIRT1 substrates such as PGC-1α and FOXO3a facilitate Sirtuin-activating compounds (STACs) activation by STacs.
Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
Basil P. Hubbard,Ana P. Gomes,Han Dai,Jun Li,April Case,Thomas Considine,Thomas V. Riera,Jessica E. Lee,E. Sook Yen,Dudley W. Lamming,Eli Schuman,Linda Stevens,Alvin J. Y. Ling,Sean M. Armour,Shaday Michan,Huizhen Zhao,Yong Jiang,Sharon Sweitzer,Charles A. Blum,Jeremy S. Disch,Pui Yee Ng,Konrad T. Howitz,Anabela P. Rolo,Yoshitomo Hamuro,Joel Moss,Robert B. Perni,James L. Ellis,George P. Vlasuk,David A. Sinclair,Bradley L. Pentelute +29 more
TL;DR: Yuan et al. as mentioned in this paper found that specific hydrophobic motifs found in SIRT1 substrates such as PGC-1α and FOXO3a facilitate SIRT 1 activation by STACs.
Journal ArticleDOI
A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
TL;DR: It is demonstrated that, biochemically, synaptotagmin 1 competes with complexin for SNARE-complex binding, thereby dislodging complexin from SNARE complexes in a Ca(2+)-dependent manner and provides a molecular explanation for the high speed and synchronicity of fast Ca( 2+)-triggered neurotransmitter release.
Journal ArticleDOI
Sirtuin activators and inhibitors : Promises, achievements, and challenges
TL;DR: Progress in understanding the mechanisms of Sirtuin modulation by such compounds provides a rational basis for further drug development.
Journal ArticleDOI
SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.
Han Dai,Lauren Kustigian,David Carney,April Case,Thomas Considine,Basil P. Hubbard,Robert B. Perni,Thomas V. Riera,Bruce G. Szczepankiewicz,George P. Vlasuk,Ross L. Stein +10 more
TL;DR: It is found that some STACs can accelerate the SIRT1-catalyzed deacetylation of specific unlabeled peptides composed only of natural amino acids, in contrast to studies reporting that peptides must bear a fluorophore for their de acetylation to be accelerated.