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Brenda J. Reinhart
Researcher at Carnegie Institution for Science
Publications - 18
Citations - 15095
Brenda J. Reinhart is an academic researcher from Carnegie Institution for Science. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 15, co-authored 18 publications receiving 14391 citations. Previous affiliations of Brenda J. Reinhart include University of Zurich & Harvard University.
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Journal ArticleDOI
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Brenda J. Reinhart,Frank J. Slack,Frank J. Slack,Michael Basson,Amy E. Pasquinelli,Bettinger Jc,Ann E. Rougvie,H R Horvitz,Gary Ruvkun +8 more
TL;DR: It is shown that let-7 is a heterochronic switch gene that encodes a temporally regulated 21-nucleotide RNA that is complementary to elements in the 3′ untranslated regions of the heteroch chronic genes lin-14, lin-28, Lin-41, lin -42 and daf-12, indicating that expression of these genes may be directly controlled by let- 7.
Journal ArticleDOI
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Amy E. Pasquinelli,Brenda J. Reinhart,Frank J. Slack,Mark Q. Martindale,Mitzi I. Kuroda,Betsy Maller,David C. Hayward,Eldon E. Ball,Bernard M. Degnan,Peter Müller,Jürg Spring,Ashok Srinivasan,Mark C. Fishman,John R. Finnerty,Joseph C. Corbo,Michael P. Levine,Patrick S. Leahy,Eric H. Davidson,Gary Ruvkun +18 more
TL;DR: Two small RNAs regulate the timing of Caenorhabditis elegans development and may control late temporal transitions during development across animal phylogeny.
Journal ArticleDOI
Prediction of Plant MicroRNA Targets
Matthew W. Rhoades,Brenda J. Reinhart,Lee P. Lim,Christopher B. Burge,Bonnie Bartel,David P. Bartel +5 more
TL;DR: This work predicts regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity and identifies members of transcription factor gene families involved in developmental patterning or cell differentiation.
PatentDOI
MicroRNAs in plants
TL;DR: Mutation of an Arabidopsis Dicer homolog, CARPEL FACTORY, prevents the accumulation of miRNAs, showing that similar mechanisms direct miRNA processing in plants and animals.
Journal ArticleDOI
A biochemical framework for RNA silencing in plants
TL;DR: This finding supports the view that plant miRNAs direct RNAi and that miRNA-specified mRNA destruction is important for proper plant development and endonuclease complexes guided by small RNAs are a common feature of RNA silencing in both animals and plants.