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Ann E. Rougvie
Researcher at University of Minnesota
Publications - 34
Citations - 7885
Ann E. Rougvie is an academic researcher from University of Minnesota. The author has contributed to research in topics: Caenorhabditis elegans & Gene. The author has an hindex of 23, co-authored 33 publications receiving 7419 citations. Previous affiliations of Ann E. Rougvie include Cornell University & Harvard University.
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Journal ArticleDOI
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Brenda J. Reinhart,Frank J. Slack,Frank J. Slack,Michael Basson,Amy E. Pasquinelli,Bettinger Jc,Ann E. Rougvie,H R Horvitz,Gary Ruvkun +8 more
TL;DR: It is shown that let-7 is a heterochronic switch gene that encodes a temporally regulated 21-nucleotide RNA that is complementary to elements in the 3′ untranslated regions of the heteroch chronic genes lin-14, lin-28, Lin-41, lin -42 and daf-12, indicating that expression of these genes may be directly controlled by let- 7.
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The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged
Ann E. Rougvie,John T. Lis +1 more
TL;DR: It is shown that a promoter-associated RNA polymerase II molecule is transcriptionally engaged and has formed a nascent RNA chain, but is apparently arrested at that point and unable to penetrate further into the hsp70 gene without heat induction.
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The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs.
Juan E. Abrahante,Aric L. Daul,Ming Li,Mandy L. Volk,Jason M. Tennessen,Eric A. Miller,Ann E. Rougvie +6 more
TL;DR: Examination of the hb 3'UTR reveals potential binding sites for known fly miRNAs and finds that hbl-1/lin-57 is regulated by let-7, at least in the nervous system, which suggests evolutionary conservation of hunchback genes may include temporal control of cell fate specification and microRNA-mediated regulation.
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C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline
TL;DR: Findings indicate that quiescence of germline development during L1 diapause is not a passive consequence of nutrient deprivation, but rather is actively maintained by DAF-18 through a pathway distinct from that which regulates longevity and dauer formation.
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Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins.
TL;DR: The Caenorhabditis elegans heterochronic genes control the relative timing and sequence of many events during postembryonic development, including the terminal differentiation of the lateral hypodermis, which occurs during the final (fourth) molt, and lin-42 most closely resembles the Period family of proteins from Drosophila and other organisms.