Brian Cox

TL;DR: It is shown that retigabine acts as a KCNQ potassium channel opener, and it is likely that M-current modulation can explain the anticonvulsant actions of retIGabine in animal models of epilepsy.

TL;DR: A new palladium(II) catalyzed methodology for the direct synthesis of alkylidene isoindolinones from N-alkoxybenzamides is presented and both systems were found to tolerate a wide range of functionality.

TL;DR: A broad range of synthetic photochemical transformations were optimized in both reactor modes and their yields and productivities compared and it was revealed that the productivity of flow reactors varied very little to that of their batch counterparts when the key reaction parameters were matched.

TL;DR: The authors describe the current technologies available for voltage-gated ion-channel screening, their application to HTS campaigns and the current limitations and emerging technologies within this area.

TL;DR: A KcsA‐based model was refined by rotating the four copies of the S6 transmembrane helix half a residue position toward the C‐terminus, so as to place all residues known to be involved in drug binding in positions lining the central cavity to produce complexes that are consistent with mutagenesis data for smaller, but not larger, ligands.