Brian P. Danysh

TL;DR: In this article , the authors performed single-cell transcriptome sequencing of 105 pretreatment and post-treatment peripheral blood mononuclear cell samples, and infusion products collected from 32 individuals with large B cell lymphoma treated with either of two CD19 CAR-T products: axicabtagene ciloleucel (axi-cel) or tisagenlecleucel(tisa-cel).

TL;DR: Rises in the normally low levels of mucin fragments in serum have been used as markers of disease, such as tumor burden, for many years and several approaches are being examined that target mucins for immunization or nanomedicine using mucin-specific antibodies.

TL;DR: It is found that ETV5 is critical for PTC cell growth, is expressed downstream of the MAPK pathway, and directly upregulates the transcription factor TWIST1, a known marker of intravasation and metastasis.

TL;DR: A novel mechanism by which ponatinib up-regulates endothelial ERK5 SUMOylation and shifts ECs to an inflammatory phenotype, disrupting vascular homeostasis is proposed.

TL;DR: The results demonstrate the promising opportunities MUC1 offers to improve the efficacy of targeted nanoparticle based approaches and their subsequent vapor nanobubble generation efficacy in the human epithelial cell line, HES.