Kara Slowik

TL;DR: Direct prospective comparison of circulating tumor DNA and tissue biopsy sequencing shows the superiority of liquid biopsies for capturing clinically relevant alterations mediating resistance to targeted therapies in cancer patients.

TL;DR: In this article, the authors identify mechanisms of SG resistance through RNA and whole-exome sequencing of pretreatment and post-progression specimens, highlighting the specificity of SG and illustrates how such mechanisms will inform therapeutic strategies to overcome ADC resistance.

TL;DR: In this article , the authors performed single-cell transcriptome sequencing of 105 pretreatment and post-treatment peripheral blood mononuclear cell samples, and infusion products collected from 32 individuals with large B cell lymphoma treated with either of two CD19 CAR-T products: axicabtagene ciloleucel (axi-cel) or tisagenlecleucel(tisa-cel).

TL;DR: This study defines RS-specific alterations and provides a molecular definition of RS, identifies distinct genetic subtypes of RS with prognostic significance, traces the evolutionary path to RS and suggests future strategies for improved detection.

TL;DR: It is shown that pirtobrutinib potently inhibits BTK-mediated functions including BCR signaling, cell viability and CCL3/CCL4 chemokine production in both BTK wild-type (WT) and C481S mutant CLL cells.