Keith Harshman

TL;DR: It is found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase during development.

TL;DR: Exome sequencing detected somatic mutations in protein-coding regions in seven melanoma cell lines and donor-matched germline cells, which showed the hallmark of UV-induced DNA repair, but such a hallmark was absent in tumor sample–specific mutations in two metastases derived from the same individual.

TL;DR: A phylogenetic analysis revealed that an ancestral vitellogenin gene first underwent a duplication that was followed by possibly independent duplications of each of the daughter viteLLogenins, possibly reflecting differential selection acting on the queen and worker castes.

TL;DR: Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world and showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy.

TL;DR: Genome-wide rhythms in RNA polymerase II loading and dynamic chromatin remodeling underlie periodic gene expression during diurnal cycles in the mouse liver.