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Brian Wigdahl
Researcher at Drexel University
Publications - 229
Citations - 6653
Brian Wigdahl is an academic researcher from Drexel University. The author has contributed to research in topics: Virus & Long terminal repeat. The author has an hindex of 41, co-authored 215 publications receiving 5987 citations. Previous affiliations of Brian Wigdahl include Thomas Jefferson University & Pennsylvania State University.
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Journal ArticleDOI
Depletion of Dendritic Cells Enhances Susceptibility to Cell-Free Infection of Human T Cell Leukemia Virus Type 1 in CD11c-Diphtheria Toxin Receptor Transgenic Mice
Saifur Rahman,Sharrón L Manuel,Zafar K. Khan,Brian Wigdahl,Edward Acheampong,Frédéric Tangy,Pooja Jain +6 more
TL;DR: Results uniquely differentiate the involvement of DCs in early cell-free versus late cell-associated infection of HTLV-1 and highlight a significant aspect of viral immunopathogenesis related to the progression of adult T cell leukemia and HTLV–associated myelopathy/tropical spastic paraparesis after the initial infection.
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Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1
TL;DR: These studies, which demonstrate significant increases in HIV-1 infection subsequent to application and removal of LC and CS, support plausible explanations for the failures of microbicides formulated from these compounds.
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Innate and adaptive factors regulating human immunodeficiency virus type 1 genomic activation.
TL;DR: Molecular mechanisms surrounding the development of latency from the site of integration to pre- and post-integration maintenance of latency, including epigenetic factors are discussed, and an understanding of the interplay of all of these factors will help guide the next generation of therapies is discussed.
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Macrophage colony stimulating factor regulation by nuclear factor kappa B: a relevant pathway in human immunodeficiency virus type 1 infected macrophages
TL;DR: It is demonstrated that nuclear factor kappa B induces M-CSF expression on a promoter level via multiple functional NF-κB binding sites and that this pathway is likely relevant in HIV-1 infection of macrophages.
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Extracellular HIV-1 Tat Mediates Increased Glutamate in the CNS Leading to Onset of Senescence and Progression of HAND.
TL;DR: This mini-review discusses the viral protein HIV-1 Tat, and its potential to induce senescence in the CNS, contributing to the development of HAND.