B
Brian Wigdahl
Researcher at Drexel University
Publications - 229
Citations - 6653
Brian Wigdahl is an academic researcher from Drexel University. The author has contributed to research in topics: Virus & Long terminal repeat. The author has an hindex of 41, co-authored 215 publications receiving 5987 citations. Previous affiliations of Brian Wigdahl include Thomas Jefferson University & Pennsylvania State University.
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Journal ArticleDOI
Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic mice
Saifur Rahman,Sharrón L Manuel,Zafar K. Khan,Brian Wigdahl,Edward Acheampong,Frédéric Tangy,Pooja Jain +6 more
TL;DR: These results uniquely differentiate the involvement of DCs in early cell-free versus late cell-associated infection of HTLV-1 and highlight a significant aspect of viral immunopathogenesis related to the progression of adult T cell leukemia and HT LV-1-associated myelopathy/tropical spastic paraparesis after the initial infection.
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Non-thermal plasma modulates cellular markers associated with immunogenicity in a model of latent HIV-1 infection.
Hager Mohamed,Ramona Clemen,Eric Freund,Jan-Wilm Lackmann,Jan-Wilm Lackmann,Kristian Wende,Jennifer Connors,Elias K. Haddad,Will Dampier,Brian Wigdahl,Vandana Miller,Sander Bekeschus,Fred C. Krebs +12 more
TL;DR: In this paper, non-thermal plasma (NTP) was used to modulate the immune response to HIV-1 that involves the use of NTP, which is an ionized gas containing various reactive oxygen and nitrogen species (RONS).
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HIV-1 Tat Length: Comparative and Functional Considerations.
Anthony R. Mele,Jamie Marino,Will Dampier,Brian Wigdahl,Brian Wigdahl,Michael R. Nonnemacher,Michael R. Nonnemacher +6 more
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the immune response to Epstein-Barr virus infection.
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Nonthermal plasma as part of a novel strategy for vaccination.
Hager Mohamed,Rita A. Esposito,Michele A. Kutzler,Brian Wigdahl,Fred C. Krebs,Vandana Miller +5 more
TL;DR: A review summarizes the opportunities for nonthermal plasma for immunization and therapeutic purposes and suggests that plasma could play an important role in improving efficacy of existing vaccines and overcoming some of the limitations and challenges with current vaccination strategies.
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Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development
TL;DR: The potential pharmacological approaches to target viral persistence and enhance effective transcription to purge the virus in cellular reservoirs, especially within the central nervous system, and the novel therapeutics that are currently in various stages of development to achieve a much superior prognosis for the HIV-1-infected population are discussed.