Brian Wigdahl

TL;DR: A model of HTLV-I-induced disease progression is presented, integrating information regarding the role of several host and viral factors in the genesis of both neoplasia and neurologic disease induced following HTLV -I infection, focusing specifically on differential viral invasion into the bone marrow (BM) and the influence of this event on the virus-specific CD8(+) cytotoxic T lymphocyte (CTL) response that is initiated following HT LV infection.

TL;DR: The structural and functional features of the cis-acting elements upstream and downstream of the transcriptional start site in the retroviral LTR and the impact of genetic variation on LTR-directed transcription during the course of retrovirus disease are reviewed.

TL;DR: This review focuses on existing and developing combination therapies, covering preclinical development, in vitro and in vivo efficacy studies, and subsequent clinical trials, and the shift in focus within the microbicide development field from single compounds to combination approaches is explored.

TL;DR: Tax contains a leucine-rich nuclear export signal (NES) that, when fused to green fluorescent protein (GFP), can direct nuclear export via the CRM-1 pathway, as determined by leptomycin B inhibition of nuclear export.

TL;DR: The murine model of toxicity is highlighted as a valuable tool for the preclinical assessment of toxicity and inflammation associated with exposure to candidate topical microbicide.