B
Brian Wigdahl
Researcher at Drexel University
Publications - 229
Citations - 6653
Brian Wigdahl is an academic researcher from Drexel University. The author has contributed to research in topics: Virus & Long terminal repeat. The author has an hindex of 41, co-authored 215 publications receiving 5987 citations. Previous affiliations of Brian Wigdahl include Thomas Jefferson University & Pennsylvania State University.
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Journal ArticleDOI
High-Affinity Interaction between HIV-1 Vpr and Specific Sequences That Span the C/EBP and Adjacent NF-κB Sites within the HIV-1 LTR Correlate with HIV-1-Associated Dementia
Tricia H. Burdo,Michael R. Nonnemacher,Bryan P. Irish,Catherine H. Choi,Fred C. Krebs,Suzanne Gartner,Brian Wigdahl +6 more
TL;DR: It is proposed that sequence-specific interactions between cis-acting elements in the LTR, members of the C/EBP family of transcription factors, and the virion-associated trans-activator protein Vpr play important roles in the pathogenesis of HIVD.
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Human immunodeficiency virus infection of the developing human nervous system
TL;DR: To approximate the intracellular events associated with HIV infection of the human fetus nervous system, cells obtained by enzymatic dissociation of aborted human fetus dorsal root ganglia and their attached spinal roots and nerves are infected.
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Human t cell lymphotropic virus type i genomic expression and impact on intracellular signaling pathways during neurodegenerative disease and leukemia
Jing Yao,Brian Wigdahl +1 more
TL;DR: It is interesting to note that it is very rare for an HTLV-I infected individual to develop both adult T cell leukemia (ATL) and TSP in his/her life time, suggesting that the mechanisms governing development of these two diseases are mutually exclusive.
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HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specific.
TL;DR: Results suggest that Vpr may regulate the interaction of members of the C/EBP transcription factor family with the viral LTR, and suggest a preference for the maintenance of two cis-acting elements with high affinity for Vpr within LTRs derived from peripheral blood.
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Induction of pro-inflammatory cytokines by human T-cell leukemia virus type-1 Tax protein as determined by multiplexed cytokine protein array analyses of human dendritic cells.
TL;DR: A role for Tax-induced cytokine secretion from MDDCs is suggested, which may be critical for the cellular activation and tissue damage that has been observed in HAM/TSP.