B
Brian Wigdahl
Researcher at Drexel University
Publications - 229
Citations - 6653
Brian Wigdahl is an academic researcher from Drexel University. The author has contributed to research in topics: Virus & Long terminal repeat. The author has an hindex of 41, co-authored 215 publications receiving 5987 citations. Previous affiliations of Brian Wigdahl include Thomas Jefferson University & Pennsylvania State University.
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Transcriptional regulation of the chemokine co-receptor CCR5 by the cAMP/PKA/CREB pathway
TL;DR: In this paper, the authors investigated the kinetics of CCR5 transcription in response to an elevation of intracellular cAMP levels and the underlying molecular events, and found that elevated cCR5 mRNA levels do not correlate with an increase in infectivity with respect to the R5 human immunodeficiency virus type 1 (HIV-1) strain.
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Cocaine Alters Cytokine Profiles in HIV-1-Infected African American Individuals in the DrexelMed HIV/AIDS Genetic Analysis Cohort
Nirzari Parikh,Will Dampier,Rui Feng,Shendra Passic,Wen Zhong,Brian Frantz,Brandon Blakey,Benjamas Aiamkitsumrit,Vanessa Pirrone,Michael R. Nonnemacher,Jeffrey M. Jacobson,Brian Wigdahl +11 more
TL;DR: Cocaine use seems to be associated with more severe HIV-1 disease, as indicated by clinical parameters such as latest viral load, CD4+ T-cell counts, and CD4:CD8 ratio.
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Murine FLT3 Ligand-Derived Dendritic Cell-Mediated Early Immune Responses Are Critical to Controlling Cell-Free Human T Cell Leukemia Virus Type 1 Infection
TL;DR: These results highlight the critical early responses generated by FL-DCs on challenge with cell-free chimeric HTLV-1 and reveal upregulation of IFN-stimulated genes, most cytokines, and transcription factors, but a distinct downregulation of many chemokines.
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AP-1-directed human T cell leukemia virus type 1 viral gene expression during monocytic differentiation
Christian Grant,Christian Grant,Pooja Jain,Michael R. Nonnemacher,Katherine E. Flaig,Bryan P. Irish,Jaya Ahuja,Aikaterini Alexaki,Timothy Alefantis,Brian Wigdahl +9 more
TL;DR: Results have suggested that following infection of peripheral blood monocytes, HTLV‐1 viral gene expression may become up‐regulated by AP‐1 during differentiation into macrophages or dendritic cells.
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Interaction between Tat and Drugs of Abuse during HIV-1 Infection and Central Nervous System Disease.
TL;DR: The individual and concerted contributions of HIV- 1 Tat, drug abuse, and ART with respect to damage in the CNS, and how these factors contribute to the development of HAND in HIV-1-infected patients are discussed.