Bruce A. Posner

TL;DR: The structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma as mentioned in this paper.

TL;DR: A unique form of autophagy-dependent cell death is identified, a Food and Drug Administration-approved class of compounds that inhibit such death, and a crucial role for Na+,K+-ATPase in its regulation is identified.

TL;DR: The drug-tolerant persister state does not limit—and may even provide a latent reservoir of cells for—the emergence of heterogeneous drug-resistance mechanisms, including the most commonly observed clinical resistance mechanisms.

TL;DR: A compound that inhibits prostaglandin degradation enhances tissue regeneration in multiple organs in mice and promotes recovery of the hematopoietic system after bone marrow transplantation, prevents the development of ulcerative colitis in the intestine, and accelerates liver regeneration after hepatic surgery.

TL;DR: Parallel screening of chemical and genetic perturbations within a panel of molecularly annotated NSCLC lines to identify intervention opportunities tightly linked to molecular response indicators predictive of target sensitivity identified three distinct target/response-indicator pairings that are represented with significant frequencies in the patient population.