B
Bruno Charbit
Researcher at Pasteur Institute
Publications - 39
Citations - 3490
Bruno Charbit is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 10, co-authored 31 publications receiving 1993 citations.
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Journal ArticleDOI
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.
Jérôme Hadjadj,Nader Yatim,Laura Barnabei,Aurélien Corneau,Jeremy Boussier,Nikaïa Smith,Hélène Péré,Bruno Charbit,Vincent Bondet,Camille Chenevier-Gobeaux,Paul Breillat,Nicolas Carlier,Rémy Gauzit,Caroline Morbieu,Frédéric Pène,Nathalie Marin,Nicolas Roche,Tali Anne Szwebel,Sarah H. Merkling,Jean-Marc Treluyer,David Veyer,Luc Mouthon,Catherine Blanc,Pierre-Louis Tharaux,Flore Rozenberg,Alain Fischer,Alain Fischer,Alain Fischer,Darragh Duffy,Frédéric Rieux-Laucat,Solen Kernéis,Solen Kernéis,Benjamin Terrier +32 more
TL;DR: The results of this trio of studies suggest that the location, timing, and duration of IFN exposure are critical parameters underlying the success or failure of therapeutics for viral respiratory infections.
Posted ContentDOI
Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients
Jérôme Hadjadj,Nader Yatim,Laura Barnabei,Aurélien Corneau,Jeremy Boussier,Hélène Péré,Bruno Charbit,Vincent Bondet,Camille Chenevier-Gobeaux,Paul Breillat,Nicolas Carlier,Remy Gauzit,Caroline Morbieu,Frédéric Pène,Nathalie Marin,Nicolas Roche,Tali-Anne Szwebel,Nikaïa Smith,Sarah H. Merkling,Jean-Marc Treluyer,David Veyer,Luc Mouthon,Catherine Blanc,Pierre-Louis Tharaux,Flore Rozenberg,Alain Fischer,Darragh Duffy,Frédéric Rieux-Laucat,Solen Kernéis,Benjamin Terrier +29 more
TL;DR: It is proposed that type-I IFN deficiency in the blood is a hallmark of severe Covid-19 and could identify and define a high-risk population and raise concern for utilization of drugs that interfere with the IFN pathway.
Journal ArticleDOI
Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients.
David M. Smadja,Coralie L. Guerin,Coralie L. Guerin,Richard Chocron,Nader Yatim,Jeremy Boussier,Nicolas Gendron,Lina Khider,Jérôme Hadjadj,Guillaume Goudot,Benjamin Debuc,Philippe Juvin,Caroline Hauw-Berlemont,Jean Loup Augy,Nicolas Peron,Emmanuel Messas,Benjamin Planquette,Olivier Sanchez,Bruno Charbit,Pascale Gaussem,Darragh Duffy,Benjamin Terrier,Tristan Mirault,Jean Luc Diehl +23 more
TL;DR: Angiopoietin-2 is a relevant predictive factor for ICU direct admission in COVID-19 patients with criteria of hospitalization for referral to intensive care unit (ICU) and/or respiratory worsening, and this result showing an endothelial activation reinforces the hypothesis of a CO VID-19-associated microvascular dysfunction.
Journal ArticleDOI
Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children
Marie-Louise Frémond,Marie-Louise Frémond,Marie-Louise Frémond,Mathieu P Rodero,Mathieu P Rodero,Nadia Jeremiah,Alexandre Belot,Eric Jeziorski,Darragh Duffy,Didier Bessis,Guilhem Cros,Gillian I. Rice,Bruno Charbit,Anne Hulin,Nihel Khoudour,Consuelo Modesto Caballero,Christine Bodemer,Monique Fabre,Laureline Berteloot,Muriel Le Bourgeois,Philippe Reix,Thierry Walzer,Despina Moshous,Stéphane Blanche,Stéphane Blanche,Alain Fischer,Brigitte Bader-Meunier,Frédéric Rieux-Laucat,Yanick J. Crow,Yanick J. Crow,Yanick J. Crow,Bénédicte Neven,Bénédicte Neven,Bénédicte Neven +33 more
TL;DR: This book aims to provide a history of Quebec and its people from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in whichMarie-Louise Frémond died.
Journal ArticleDOI
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges
Barbara Piasecka,Darragh Duffy,Alejandra Urrutia,Alejandra Urrutia,Hélène Quach,Etienne Patin,Celine Posseme,Jacob Bergstedt,Bruno Charbit,Vincent Rouilly,Cameron Ross MacPherson,Milena Hasan,Benoit Albaud,David Gentien,Jacques Fellay,Jacques Fellay,Matthew L. Albert,Matthew L. Albert,Lluis Quintana-Murci +18 more
TL;DR: The respective effects of age, sex, genetics, and cellular heterogeneity on the interindividual variability of immune responses are quantified and constitutes a valuable resource for further exploration in the context of different infection risks or disease outcomes.