L
Laura Barnabei
Researcher at University of Paris
Publications - 20
Citations - 2674
Laura Barnabei is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 4, co-authored 13 publications receiving 1486 citations.
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Journal ArticleDOI
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.
Jérôme Hadjadj,Nader Yatim,Laura Barnabei,Aurélien Corneau,Jeremy Boussier,Nikaïa Smith,Hélène Péré,Bruno Charbit,Vincent Bondet,Camille Chenevier-Gobeaux,Paul Breillat,Nicolas Carlier,Rémy Gauzit,Caroline Morbieu,Frédéric Pène,Nathalie Marin,Nicolas Roche,Tali Anne Szwebel,Sarah H. Merkling,Jean-Marc Treluyer,David Veyer,Luc Mouthon,Catherine Blanc,Pierre-Louis Tharaux,Flore Rozenberg,Alain Fischer,Alain Fischer,Alain Fischer,Darragh Duffy,Frédéric Rieux-Laucat,Solen Kernéis,Solen Kernéis,Benjamin Terrier +32 more
TL;DR: The results of this trio of studies suggest that the location, timing, and duration of IFN exposure are critical parameters underlying the success or failure of therapeutics for viral respiratory infections.
Posted ContentDOI
Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients
Jérôme Hadjadj,Nader Yatim,Laura Barnabei,Aurélien Corneau,Jeremy Boussier,Hélène Péré,Bruno Charbit,Vincent Bondet,Camille Chenevier-Gobeaux,Paul Breillat,Nicolas Carlier,Remy Gauzit,Caroline Morbieu,Frédéric Pène,Nathalie Marin,Nicolas Roche,Tali-Anne Szwebel,Nikaïa Smith,Sarah H. Merkling,Jean-Marc Treluyer,David Veyer,Luc Mouthon,Catherine Blanc,Pierre-Louis Tharaux,Flore Rozenberg,Alain Fischer,Darragh Duffy,Frédéric Rieux-Laucat,Solen Kernéis,Benjamin Terrier +29 more
TL;DR: It is proposed that type-I IFN deficiency in the blood is a hallmark of severe Covid-19 and could identify and define a high-risk population and raise concern for utilization of drugs that interfere with the IFN pathway.
Journal ArticleDOI
Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients.
Marie-Louise Frémond,Marie-Louise Frémond,Alice Hadchouel,Alice Hadchouel,Alice Hadchouel,Laureline Berteloot,Isabelle Melki,Isabelle Melki,Violaine Bresson,Laura Barnabei,Nadia Jeremiah,Alexandre Belot,Vincent Bondet,Olivier Brocq,Damien Chan,Rawane Dagher,Jean-Christophe Dubus,Darragh Duffy,Séverine Feuillet-Soummer,Mathieu Fusaro,Mathieu Fusaro,Marco Gattorno,Antonella Insalaco,Eric Jeziorski,Naoki Kitabayashi,Mireia Lopez-Corbeto,Françoise Mazingue,Marie-Anne Morren,Marie-Anne Morren,Gillian I. Rice,Jacques G. Rivière,Luis Seabra,Jérôme Sirvente,Pere Soler-Palacín,Nathalie Stremler-Le Bel,Guillaume Thouvenin,Caroline Thumerelle,Eline Van Aerde,Stefano Volpi,Sophie Willcocks,Carine Wouters,Carine Wouters,Sylvain Breton,Thierry Jo Molina,Thierry Jo Molina,Brigitte Bader-Meunier,Brigitte Bader-Meunier,Despina Moshous,Despina Moshous,Alain Fischer,Alain Fischer,Alain Fischer,Stéphane Blanche,Stéphane Blanche,Frédéric Rieux-Laucat,Yanick J. Crow,Yanick J. Crow,Bénédicte Neven,Bénédicte Neven +58 more
TL;DR: This largest worldwide cohort of SAVI patients precise core features are described and extends the clinical and immunological phenotype of the disease, displaying overlap with other monogenic interferonopathies.
Journal ArticleDOI
Platelet activation in critically ill COVID-19 patients.
Nader Yatim,Jeremy Boussier,Richard Chocron,Jérôme Hadjadj,Aurélien Philippe,Nicolas Gendron,Laura Barnabei,Bruno Charbit,T.-A. Szwebel,Nicolas Carlier,Frédéric Pène,Celia Azoulay,Lina Khider,Tristan Mirault,Jean-Luc Diehl,Coralie L. Guerin,Frédéric Rieux-Laucat,Darragh Duffy,Solen Kernéis,David M. Smadja,Benjamin Terrier +20 more
TL;DR: In this paper, the authors explored two independent cross-sectional cohorts to identify soluble markers and gene-expression signatures that discriminated COVID-19 severity and outcomes, and found that elevated soluble (s)P-selectin at admission was associated with disease severity.
Journal ArticleDOI
A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis.
Camille de Cevins,Marine Luka,Marine Luka,Nikaïa Smith,Sonia Meynier,Aude Magérus,Francesco Carbone,Francesco Carbone,Victor Garcia-Paredes,Victor Garcia-Paredes,Laura Barnabei,Maxime Batignes,Alexandre Boullé,Marie-Claude Stolzenberg,Brieuc P. Perot,Bruno Charbit,Tinhinane Fali,Vithura Pirabarakan,Boris Sorin,Quentin Riller,Ghaith Abdessalem,Maxime Beretta,Ludivine Grzelak,Pedro Gonçalves,James P. Di Santo,Hugo Mouquet,Olivier Schwartz,Mohammed Zarhrate,Mélanie Parisot,Christine Bole-Feysot,Cécile Masson,Nicolas Cagnard,Aurélien Corneau,Camille Bruneau,Shen-Ying Zhang,Shen-Ying Zhang,Jean-Laurent Casanova,Jean-Laurent Casanova,Jean-Laurent Casanova,Brigitte Bader Meunier,Julien Haroche,Isabelle Melki,Isabelle Melki,Mathie Lorrot,Mehdi Oualha,Florence Moulin,Damien Bonnet,Zahra Belhadjer,Marianne Leruez,Slimane Allali,Christele Gras Leguen,Loïc de Pontual,Alain Fischer,Alain Fischer,Alain Fischer,Darragh Duffy,Frédéric Rieux-Laucat,Julie Toubiana,Julie Toubiana,Mickaël M. Ménager,Mickaël M. Ménager +60 more
TL;DR: The most severe forms of multisystem inflammatory syndrome in children related to SARS-CoV-2, that resulted in myocarditis, were characterized by elevated levels of pro-angiogenesis cytokines and several chemokines, and a weak response to type-I and type-II interferons, hyperinflammation and response to oxidative stress related to increased HIF-1α and VEGF signaling.