C
Caroline Morbieu
Researcher at University of Paris
Publications - 22
Citations - 3384
Caroline Morbieu is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 6, co-authored 13 publications receiving 2112 citations.
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Journal ArticleDOI
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.
Jérôme Hadjadj,Nader Yatim,Laura Barnabei,Aurélien Corneau,Jeremy Boussier,Nikaïa Smith,Hélène Péré,Bruno Charbit,Vincent Bondet,Camille Chenevier-Gobeaux,Paul Breillat,Nicolas Carlier,Rémy Gauzit,Caroline Morbieu,Frédéric Pène,Nathalie Marin,Nicolas Roche,Tali Anne Szwebel,Sarah H. Merkling,Jean-Marc Treluyer,David Veyer,Luc Mouthon,Catherine Blanc,Pierre-Louis Tharaux,Flore Rozenberg,Alain Fischer,Alain Fischer,Alain Fischer,Darragh Duffy,Frédéric Rieux-Laucat,Solen Kernéis,Solen Kernéis,Benjamin Terrier +32 more
TL;DR: The results of this trio of studies suggest that the location, timing, and duration of IFN exposure are critical parameters underlying the success or failure of therapeutics for viral respiratory infections.
Journal ArticleDOI
Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data.
Matthieu Mahevas,Viet-Thi Tran,Mathilde Roumier,Amélie Chabrol,Romain Paule,Constance Guillaud,Elena Fois,Raphaël Lepeule,Tali Anne Szwebel,François Xavier Lescure,Frédéric Schlemmer,Marie Matignon,Mehdi Khellaf,Etienne Crickx,Benjamin Terrier,Caroline Morbieu,Paul Legendre,Julien Dang,Yoland Schoindre,Jean-Michel Pawlotsky,Marc Michel,Elodie Perrodeau,Nicolas Carlier,Nicolas Roche,Victoire de Lastours,Clément Ourghanlian,Solen Kernéis,Philippe Ménager,Luc Mouthon,Etienne Audureau,Philippe Ravaud,Bertrand Godeau,S. Gallien,Nathalie Costedoat-Chalumeau +33 more
TL;DR: Hydxychloroquine has received worldwide attention as a potential treatment for covid-19 because of positive results from small studies, but the results of this study do not support its use in patients admitted to hospital with covids-19 who require oxygen.
Posted ContentDOI
Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients
Jérôme Hadjadj,Nader Yatim,Laura Barnabei,Aurélien Corneau,Jeremy Boussier,Hélène Péré,Bruno Charbit,Vincent Bondet,Camille Chenevier-Gobeaux,Paul Breillat,Nicolas Carlier,Remy Gauzit,Caroline Morbieu,Frédéric Pène,Nathalie Marin,Nicolas Roche,Tali-Anne Szwebel,Nikaïa Smith,Sarah H. Merkling,Jean-Marc Treluyer,David Veyer,Luc Mouthon,Catherine Blanc,Pierre-Louis Tharaux,Flore Rozenberg,Alain Fischer,Darragh Duffy,Frédéric Rieux-Laucat,Solen Kernéis,Benjamin Terrier +29 more
TL;DR: It is proposed that type-I IFN deficiency in the blood is a hallmark of severe Covid-19 and could identify and define a high-risk population and raise concern for utilization of drugs that interfere with the IFN pathway.
Journal ArticleDOI
Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial
Pierre-Louis Tharaux,Gilles Pialoux,Arthur Pavot,Xavier Mariette,Olivier Hermine,Matthieu Resche-Rigon,Raphaël Porcher,Philippe Ravaud,Serge Bureau,Maxime Dougados,Annick Tibi,Elie Azoulay,Jacques Cadranel,Joseph Emmerich,Muriel Fartoukh,Bertrand Guidet,Marc Humbert,Karine Lacombe,Matthieu Mahévas,Frédéric Pène,Valérie Pourchet-Martinez,Frédéric Schlemmer,Yazdan Yazdanpanah,Gabriel Baron,Elodie Perrodeau,Damien Vanhoye,Cécile Kedzia,Lauren Demerville,Anne Gysembergh-Houal,Alexandre Bourgoin,Sarah Dalibey,Nabil Raked,Lakhdar Mameri,Stéphanie Alary,Samir Hamiria,Thinhinane Bariz,Hala Semri,Dhiaa Meriem Hai,Moustafa Benafla,Mohamed Belloul,Pernelle Vauboin,Saskia Flamand,Claire Pacheco,Anouk Walter-Petrich,Emilia Stan,Souad Benarab,Corine Nyanou,Claire Montlahuc,Lucie Biard,Robin Charreteur,Celine Dupré,Kévin Cardet,Blandine Lehmann,Kamyl Baghli,Claire Madelaine,Eric D'Ortenzio,Oriane Puéchal,Caroline Semaille,Laurent Savale,Anatole Harrois,Samy Figueiredo,Jacques Duranteau,Nadia Anguel,Xavier Monnet,Christian Richard,Jean-Louis Teboul,Philippe Durand,Pierre Tissieres,Mitja Jevnikar,David Montani,Sophie Bulifon,Xavier Jaïs,Olivier Sitbon,Stéphan Pavy,Nicolas Noel,Olivier Lambotte,Lelia Escaut,Stéphane Jauréguiberry,Elodie Baudry,Christiane Verny,Mathilde Noaillon,Edouard Lefèvre,Mohamad Zaidan,Clotilde Le Tiec Le Tiec,Céline Verstuyft Verstuyft,Anne-Marie Roques,Lamiae Grimaldi,Domitille Molinari,Gaël Leprun,Alain Fourreau,Laurent Cylly,Myriam Virlouvet,Ramdane Meftali,Solène Fabre,Marion Licois,Asmaa Mamoune,Yacine Boudali,Sophie Georgin-Lavialle,Patricia Senet,A Soria,Antoine Parrot,Hélène François,Nathalie Rozensztajn,Emmanuelle Blin,Pascaline Choinier,Juliette Camuset,Jean-Simon Rech,Antony Canellas,Camille Rolland-Debord,Nadège Lemarié,Nicolas Belaube,Marine Nadal,Martin Siguier,Camille Petit-Hoang,Julie Chas,Elodie Drouet,Matthieu Lemoine,Audrey Phibel,Lucie Aunay,Eliane Bertrand,Sylviane Ravato,Marie Vayssettes,Anne Adda,Celine Wilpotte,Pélagie Thibaut,Julie Fillon,Isabelle Debrix,Soraya Fellahi,Jean-Philippe Bastard,Guillaume Lefèvre,Vincent Fallet,Jacques-Eric Gottenberg,Yves Hansmann,Emmanuel Andrès,Sophie Bayer,Guillaume Becker,Frédéric Blanc,Stéphane Brin,Vincent Castelain,Emmanuel Chatelus,Eva Chatron,Olivier Collange,François Danion,Frédéric De Blay,Eric Demonsant,Pierre Diemunsch,Sophie Diemunsch,Renaud Felten,Bernard Goichot,Valentin Greigert,Aurélien Guffroy,Bob Heger,Anne Hutt,Charlotte Kaeuffer,Loic Kassegne,Anne Sophie Korganow,Pierrick Le Borgne,Nicolas Lefebvre,Tristan Martin,Paul Michel Mertes,Catherine Metzger,Nicolas Meyer,Gabriel Nisand,Eric Noll,Mathieu Oberlin,Sophie Ohlmann-Caillard,Vincent Poindron,Julien Pottecher,Yvon Ruch,Cédric Sublon,Hakim Tayebi,François Weill,Arsène Mekinian,Dorothée Chopin,Olivier Fain,Marc Garnier,Jessica Krause le Garrec,Marjolaine Morgand,Jérôme Pacanowski,Tomas Urbina,Chloe McAvoy,Maria Pereira,Gladys Aratus,Laurence Berard,Tabassome Simon,Anne Daguenel-Nguyen,Marie Antignac,Céline Leplay,Jean-Benoit Arlet,Jean-Luc Diehl,Florence Bellenfant,Anne Blanchard,Alexandre Buffet,Bernard Cholley,Antoine Fayol,Edouard Flamarion,Anne Godier,Thomas Gorget,Sophie-Rym Hamada,Caroline Hauw-Berlemont,Jean-Sébastien Hulot,David Lebeaux,Marine Livrozet,Adrien Michon,Arthur Neuschwander,Marie-Aude Penet,Benjamin Planquette,Brigitte Ranque,Olivier Sanchez,Geoffroy Volle,Sandrine Briois,Mathias Cornic,Virginie Elisee,Jesuthasan Denis,Juliette Djadi-Prat,Pauline Jouany,Ramon Junquera,Mickael Henriques,Amina Kebir,Isabelle Lehir,Jeanne Meunier,Florence Patin,Valérie Paquet,Anne Tréhan,Véronique Vigna,Brigitte Sabatier,Damien Bergerot,Charléne Jouve,Camille Knosp,Olivia Lenoir,Nassim Mahtal,Léa Resmini,F-Xavier Lescure,Jade Ghosn,Antoine Bachelard,Timothee Bironne,Raphael Borie,Agathe Bounhiol,Catherine Boussard,Jeanne CHAUFFiER,Solaya Chalal,Lynda Chalal,Malikhone Chansombat,Paul Crespin,Bruno Crestani,Olivia Daconceicao,Laurène Deconinck,Philippe Dieudé,A. Dossier,Marie Dubert,Greggory Ducrocq,Axelle Fuentes,A Gervais,Marie Gilbert,Valentina Isernia,Sophie Ismael,Veronique Joly,Z Julia,S Lariven,Sylvie Le Gac,Diane Le Pluart,F Louni,Awa Ndiaye,Thomas Papo,Marion Parisey,Bao Phung,Annabelle Pourbaix,Anne Rachline,C Rioux,Aurelie Sautereau,Gabriel Steg,Hassan Tarhini,Simon Valayer,Dorothee Vallois,Paul Vermes,Thomas Volpe,Yann Nguyen,Vasco Honsel,Emmanuel Weiss,Anaïs Codorniu,Virginie Zarrouk,Victoire De Lastours,Matthieu Uzzan,Olivier Olivier,Geoffrey Rossi,Naura Gamany,Roza Rahli,Zeina Louis,David Boutboul,Lionel Galicier,Yaël Amara,Gabrielle Archer,Amira Benattia,Anne Bergeron,Louise Bondeelle,Nathalie De Castro,Melissa Clément,Michaël Darmont,Blandine Denis,Clairelyne Dupin,Elsa Feredj,Delphine Feyeux,Adrien Joseph,Etienne Lengliné,Pierre Le Guen,Geoffroy Liégeon,Gwenaël Lorillon,Asmaa Mabrouki,Eric Mariotte,Grégoire Martin de Frémont,Adrien Mirouse,Jean-Michel Molina,Régis Peffault de Latour,Eric Oksenhendler,Julien Saussereau,Abdellatif Tazi,Jean-Jacques Tudesq,Lara Zafrani,Isabelle Brindele,Emmanuelle Bugnet,Karine Celli Lebras,Julien Chabert,Lalia Djaghout,Catherine Fauvaux,Anne Lise Jegu,Ewa Kozaliewicz,Martine Meunier,Marie-Thérèse Tremorin,Claire Davoine,Isabelle Madeleine,Sophie Caillat-Zucman,Constance Delaugerre,Florence Morin,Damien Sène,Ruxandra Burlacu,Benjamin G. Chousterman,Bruno Mégarbane,Pascal Richette,Jean-Pierre Riveline,Aline Frazier,Eric Vicaut,Laure Berton,Tassadit Hadjam,Miguel Alejandro Vasquez-Ibarra,Clément Jourdaine,Aude Jacob,Julie Smati,Stéphane Renaud,Philippe Manivet,Claire Pernin,Lydia Suarez,Luca Semerano,Sebastien Abad,Ruben Benainous,Coralie Bloch Queyrat,Nicolas Bonnet,Sabrina Brahmi,johann Cailhol,Yves Cohen,Celine Comparon,Hugues Cordel,Robin Dhote,Nathalie Dournon,B. Duchemann,Nathan Ebstein,Benedicte Giroux-Leprieur,Jeanne Goupil de Bouille,Anne Jacolot,Hilario Nunes,Johanna Oziel,Vanessa Rathouin,Marthe Rigal,Dominique Roulot,Claire Tantet,Yurdagul Uzunhan,Nathalie Costedoat-Chalumeau,Zakaria Ait Hamou,Sarah Benghanem,Philippe Blanche,Etienne Canouï,Nicolas Carlier,Benjamin Chaigne,Adrien Contejean,Bertrand Dunogue,Pierre Dupland,Aurélie Durel Maurisse,Rémy Gauzit,Paul Jaubert,Hassan Joumaa,Mathieu Jozwiak,Solen Kernéis,Marie Lachatre,Hélène Lafoeste,Paul Legendre,Liem Binh Luong Nguyen,Jonathan Marey,Caroline Morbieu,Luc Mouthon,Lee S. Nguyen,Lola-Jade Palmieri,Alexis Régent,Tali-Anne Szwebel,Benjamin Terrier,Corinne Guerin,Jérémie Zerbit,Kahina Cheref,Kamil Chitour,Mamadou Salif Cisse,Ada Clarke,Gaelle Clavere,Isabelle Dusanter,Caroline Gaudefroy,Moez Jallouli,Sami Kolta,Catherine Le Bourlout,Nathalie Marin,Nathalie Menage,Alexandre Moores,Isabelle Peigney,Cédric Pierron,Samira Saleh-Mghir,Mathilde Vallet,Marc Michel,Giovanna Melica,Jean-Daniel Lelievre,Elena Fois,Pascal Lim,Marie Matignon,Constance Guillaud,Alaki Thiemele,David Schmitz,Marion Bouhris,Syllia Belazouz,Laetitia Languille,Armand Mekontso-Dessaps,Thiziri Sadaoui,Julien Mayaux,Patrice Cacoub,Jean-Christophe Corvol,Céline Louapre,Sara Sambin,Louise-Laure Mariani,Carine Karachi,Florence Tubach,Candice Estellat,Linda Gimeno,Karine Martin,Aïcha Bah,Vixra Keo,Sabrine Ouamri,Yasmine Messaoudi,Nessima Yelles,Pierre Faye,Sébastien Cavelot,Cecile Larcheveque,Laurence Annonay,Jaouad Benhida,Aida Zahrate-Ghoul,Soumeya Hammal,Ridha Belilita,Marie Lecronier,Alexandra Beurton,Luc Haudebourg,Robin Deleris,Julien Le Marec,Sara Virolle,Safaa Nemlaghi,Côme Bureau,Pierre Mora,Martin De Sarcus,Olivier Clovet,Baptiste Duceau,Paul Henri Grisot,Marie hélène Pari,Jeremy Arzoine,Ulrich Clarac,Morgane Faure,Julie Delemazure,Maxence Decavele,Elise Morawiec,Alexandre Demoule,Martin Dres,Mathieu Vautier,Yves Allenbach,Olivier Benveniste,Gaelle Leroux,Aude Rigolet,Perrine Guillaume-Jugnot,Fanny Domont,Anne Claire Desbois,Cloé Comarmond,Nicolas Champtiaux,Segolene Toquet,Amine Ghembaza,Matheus Vieira,Georgina Maalouf,Gonçalo Boleto,Yasmina Ferfar,Fanny Charbonnier,Claire Aguilar,Fanny Alby-Laurent,Marie-Alexandra Alyanakian,Prissile Bakouboula,Christine Broissand,Carole Burger,Clara Campos-Vega,Nathalie Chavarot,Laure Choupeaux,Benjamin Fournier,Sophie Granville,Elodie Issorat,Claire Rouzaud,Damien Vimpere,Guillaume Geri,Nawal Derridj,Naima Sguiouar,Hakim Meddah,Mourad Djadel,Helene Chambrin-Lauvray,Jean-Charles Duclos-Vallée,Faouzi Saliba,Sophie-Caroline Sacleux,Ilias Koumis,Jean-Marie Michot,Annabelle Stoclin,Emeline Colomba,Fanny Pommeret,Chistophe Willekens,Madona Sakkal,Rosa Da Silva,Valérie Dejean,Yasmina Mekid,Ines Ben-Mabrouk,Caroline Pradon,Laurence Drouard,Valérie Camara-Clayette,Alexandre Morel,Gilles Garcia,Abolfazl Mohebbi,Férial Berbour,Mélanie Dehais,Anne-Lise Pouliquen,Alison Klasen,Loren Soyez-Herkert,Jonathan London,Younes Keroumi,Emmanuelle Guillot,Guillaume Grailles,Younes El Amine,Fanny Defrancq,Hanane Fodil,Chaouki Bouras,Dominique Dautel,Nicolas Gambier,Thierno Dieye,Anaïs Razurel,Boris Bienvenu,Victor Lancon,Laurence Lecomte,Kristina Beziriganyan,Belkacem Asselate,Laure Allanic,Elena Kiouris,Marie-Hélène Legros,Christine Lemagner,Pascal Martel,Vincent Provitolo,Félix Ackermann,Mathilde Le Marchand,Aurélie Clan Hew Wai,Dimitri Fremont,Elisabeth Coupez,Mireille Adda,Frédéric Duée,Lise Bernard,Antoine Gros,Estelle Henry,Claire Courtin,Anne Pattyn,Pierre-Grégoire Guinot,Marc Bardou,Agnes Maurer,Julie Jambon,Amélie Cransac,Corinne Pernot,Bruno Mourvillier,Amélie Servettaz,Gaëtan Deslée,Alain Wynckel,Philippe Benoit,Eric Marquis,Damien Roux,Coralie Gernez,Cécile Yelnik,Julien Poissy,Mandy Nizard,Fanette Denies,Hélène Gros,Jean-Jacques Mourad,Emmanuelle Sacco,Sophie Renet +600 more
TL;DR: Anakinra did not improve outcomes in patients with mild-to-moderate COVID-19 pneumonia, and further studies are needed to assess the efficacy of anakinra in other selected groups of patients with more severe CO VID-19.
Posted ContentDOI
No evidence of clinical efficacy of hydroxychloroquine in patients hospitalized for COVID-19 infection with oxygen requirement: results of a study using routinely collected data to emulate a target trial
Matthieu Mahévas,Viet-Thi Tran,Mathilde Roumier,Amélie Chabrol,Romain Paule,Constance Guillaud,S. Gallien,Raphaël Lepeule,Tali-Anne Szwebel,Xavier Lescure,Frédéric Schlemmer,Marie Matignon,Medhi Khellaf,Etienne Crickx,Benjamin Terrier,Caroline Morbieu,Paul Legendre,Julien Dang,Yoland Schoindre,Jean-Michel Pawlotski,Marc Michel,Elodie Perrodeau,Nicolas Carlier,Nicolas Roche,Victoire de Lastours,Luc Mouthon,Etienne Audureau,Philippe Ravaud,Bertrand Godeau,Nathalie Costedoat-Chalumeau +29 more
TL;DR: The results do not support the use of HCQ in patients hospitalised for documented SARS-CoV-2-positive hypoxic pneumonia, and a target trial aimed at assessing the effectiveness ofHCQ at 600 mg/day is emulated.