B
Bruno de Sousa
Researcher at University of Coimbra
Publications - 76
Citations - 1173
Bruno de Sousa is an academic researcher from University of Coimbra. The author has contributed to research in topics: Health care & Population. The author has an hindex of 18, co-authored 68 publications receiving 952 citations. Previous affiliations of Bruno de Sousa include Universidade Nova de Lisboa & University of Aveiro.
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Extremal indices, geometric ergodicity of Markov chains, and MCMC
TL;DR: In this article, the connections between extremal indices and stability of Markov chains were investigated, and a close link between the extremal index and geometric ergodicity was found.
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Dynamics of cytokines and immunoglobulins serum profiles in primary and secondary Cryptosporidium parvum infection: usefulness of Luminex® xMAP technology.
Vera Codices,Catarina Martins,Carlos Novo,Bruno de Sousa,Ângela Lopes,Miguel Borrego,Olga Matos +6 more
TL;DR: A better understanding of the immune response to the infection by C. parvum is contributed to, as well as the advantage of Luminex® xMAP technology to study immune mediators, using small sample volumes is demonstrated.
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The 15-item Systemic Clinical Outcome and Routine Evaluation (SCORE-15) Scale: Portuguese Validation Studies
TL;DR: This study reports on the validity of the 15-item Portuguese version of the Systemic Clinical Outcome Routine Evaluation (SCORE-15), a brief and comprehensive measure of family functioning, and analyses the discriminant, convergent and predictive validity of this version.
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Development of mathematical models for the analysis of hepatitis delta virus viral dynamics.
Bruno de Sousa,Celso Cunha +1 more
TL;DR: The simulation study shows that, under the most commonly used and generally accepted therapy approaches for HDV infection, LMV monotherapy and combination therapy of LMV and IFN were predicted to more effectively reduce the HBV and HDV viral loads in the case of super-infection scenarios when compared with the co-infections.
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Nonclassic metallointercalators with dipyridophenazine: DNA interaction studies and leishmanicidal activity.
João Madureira,João Madureira,Catarina I. V. Ramos,Mónica Marques,Carla Maia,Bruno de Sousa,Lenea Campino,M. Graça Santana-Marques,Nicholas Farrell +8 more
TL;DR: Combined analysis of DNA biophysical studies, parasite activity, and cytotoxicity measurements suggests that intercalation correlates with leishmanicidal activity, while cytot toxicity results are justified by a combination of DNA interCalation and possible radical formation in the case of Cu(II), most probably hydroxyl and/or singlet oxygen radicals.