Jennifer C. Drew

TL;DR: Three lines of evidence are presented that support the notion that, as healthy infants approach the toddler stage, their microbiomes become healthier and more stable, whereas, children who are destined for autoimmunity develop a microbiome that is less diverse and stable.

TL;DR: Detailed differences in metabolic potential indicate that autoimmune subjects have a functionally aberrant microbiome, and data suggest that a consortium of lactate- and butyrate-producing bacteria in a healthy gut induce a sufficient amount of mucin synthesis to maintain gut integrity.

TL;DR: This work provides the first evidence to support the hypothesis that the fetal intestinal microbiome derived from swallowed amniotic fluid may be involved in the inflammatory response that leads to premature birth.

TL;DR: The early development of the gut microbiomes of 76 children at high genetic risk for T1D was determined using high-throughput 16S rRNA gene sequencing, and one highly abundant group, composed of two closely related species, B. dorei and Bacteroides vulgatus, was significantly higher in cases compared to controls prior to seroconversion.

TL;DR: No differences between anti-islet cell autoantibody–positive and –negative children were found in bacterial diversity, microbial composition, or single-genus abundances, however, substantial alterations in microbial interaction networks were observed at age 0.5 and 2 years in the children in whom anti- islet cellAutoantibodies developed.