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Bryan R. Cullen
Researcher at Duke University
Publications - 376
Citations - 52946
Bryan R. Cullen is an academic researcher from Duke University. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 121, co-authored 371 publications receiving 50901 citations. Previous affiliations of Bryan R. Cullen include Hoffmann-La Roche & University of Medicine and Dentistry of New Jersey.
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Endogenous avian retroviruses contain deficient promoter and leader sequences
TL;DR: Unexpectedly, an additional defect outside of the LTR in the 5' noncoding leader sequence of ev-1 that further decreases gene expression relative to RAV-0 by approximately equal to 10-fold is detected.
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Visna virus encodes a post-transcriptional regulator of viral structural gene expression
Laurence Tiley,Pamela H. Brown,Shu Yun Le,Jacob V. Maizel,Janice E. Clements,Bryan R. Cullen +5 more
TL;DR: Replication of HIV-1 and of other complex primate retroviruses requires the expression in trans of a virally encoded post-transcriptional activator of viral structural gene expression termed Rev (HIV-1) or Rex (HTLV-I).
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Genetic evidence that the Tat proteins of human immunodeficiency virus types 1 and 2 can multimerize in the eukaryotic cell nucleus.
TL;DR: Mutational analysis indicates a critical role for the essential core motif of Tat in mediating this interaction but demonstrates that efficient Tat multimerization does not require an intact cysteine motif, raising the possibility that the multimerized of Tat may be important for Tat function in higher eukaryotes.
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Identification of Novel, Highly Expressed Retroviral MicroRNAs in Cells Infected by Bovine Foamy Virus
Adam W. Whisnant,Timo Kehl,Qiuying Bao,Magdalena Materniak,Jacek Kuzmak,Martin Löchelt,Bryan R. Cullen +6 more
TL;DR: It is demonstrated that bovine foamy virus (BFV) expresses high levels of three viral microRNAs (miRNAs) in BFV-infected cells in culture and also in infected cattle, which suggests that these miRNAs may exert a significant effect on viral replication in vivo.
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The human foamy virus Bel-1 transcription factor is a sequence-specific DNA binding protein.
TL;DR: The Bel-1 transcriptional transactivator encoded by human foamy virus can efficiently activate gene expression directed by both the HFV long terminal repeat (LTR) and internal promoter elements and is unique among retroviral regulatory proteins in being a sequence-specific DNA binding protein.