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Bryan R. Cullen
Researcher at Duke University
Publications - 376
Citations - 52946
Bryan R. Cullen is an academic researcher from Duke University. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 121, co-authored 371 publications receiving 50901 citations. Previous affiliations of Bryan R. Cullen include Hoffmann-La Roche & University of Medicine and Dentistry of New Jersey.
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APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells
TL;DR: The results argue that APOBEC3A inhibits IAP retrotransposition via a novel mechanism that is distinct from, and in this case more effective than, the DNA editing mechanism characteristic of APOBec3G and APOB EC3B.
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Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein.
TL;DR: Mutagenesis of this sequence in the tat gene of human immunodeficiency virus type 1 is shown to reduce, but not eliminate, the trans-activation of human Immunodeficiencies 1-specific gene expression.
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Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors.
TL;DR: Metazoan organisms are subject to invasion by a wide range of microbial pathogens and have, as a result, evolved a range of defensive measures, including antibodies and cytotoxic T cells.
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A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors
Mitchell Dukovich,Mitchell Dukovich,Yuji Wano,Yuji Wano,Le thi Rich Thuy,Paul Katz,Bryan R. Cullen,John H. Kehrl,Warner C. Greene,Warner C. Greene +9 more
TL;DR: The identification of a second human IL-2 binding protein that has an M r of ˜70K, lacks reactivity with the anti-Tac antibody, and is present on the surface of resting T cells, large granular lymphocytes (natural killer cells), and certain T and B cell lines in the absence of the Tac antigen suggest that the high-affinity humanIL-2 receptor may be a membrane complex composed of at least the p70 protein and Tac antigen.
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Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection.
TL;DR: It is hypothesized that downregulation of cell-surface CD4 by Nef facilitates the efficient release of infectious progeny virions and, hence, viral spread in vivo.