Bryan R. Cullen

TL;DR: It is demonstrated that NXF3, a human RNA binding protein related to TAP, lacks a carboxy-terminal domain yet retains the ability to export tethered RNA transcripts and to shuttle between the nucleus and the cytoplasm.

TL;DR: Three recent papers provide evidence that either favors or challenges the antiviral role of RNA interference in mammals, and are discussed in the context of previous research.

TL;DR: It is reported that amphibian TFIIIA proteins contain a sequence element with homology to the Rev activation domain that effectively substitutes for this domain in inducing the nuclear export of late HIV-1 mRNAs and 5S rRNA transcripts.

TL;DR: It is suggested that VP16, like Tat, can act on steps subsequent to the formation of the HIV-1 LTR preinitiation complex and the finding that the activation domains of VP16 and Tat are functionally interchangeable raises the possibility that these apparently disparate viral trans-activators may nevertheless act via similar mechanisms.

TL;DR: The data demonstrate that the biological activity of the RelA activation domain is dependent on acidic activator sequences that are closely comparable to those detected in the activation domain of the viral VP16 regulatory protein.