Bryan R. Cullen

TL;DR: This research analyzed the pattern of small RNA expression in vivo using latently RRV-infected B-cell lymphoma and retroperitoneal fibromatosis tissues and identified 15 virally encoded pre-miRNAs in both tumors, including all previously reported RRV pre- miRNAs.

TL;DR: The data presented in the present study demonstrate that MLV RNAs bear an exceptionally high level of the epitranscriptomic modifications m6A, m5C, and Nm, suggesting that these each facilitate some aspect of the viral replication cycle, and demonstrate that mutational removal of a subset of these m 6A or m 5C modifications from MLV transcripts inhibits MLV replication in cis.

TL;DR: Together, these data indicate that Tap belongs to a novel class of RNA export factors that can target bound RNA molecules directly to the nuclear pore without the assistance of an importin β-like cofactor.

TL;DR: It is reported that expression of eCycT1 in human cells fully rescues eTat function and that eCyCT1 and eT at form a protein complex that specifically binds to the EIAV, but not the HIV-1, TAR element.

TL;DR: It is demonstrated that a CTE previously proposed to be present in the avian sarcoma/leukemia (ASV/ALV) family of retroviruses indeed functions as a potent RNA export signal and the secondary structure and biological activity of an avian CTE sequence that may access a novel nuclear RNA export pathway.