B
Bryan R. Cullen
Researcher at Duke University
Publications - 376
Citations - 52946
Bryan R. Cullen is an academic researcher from Duke University. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 121, co-authored 371 publications receiving 50901 citations. Previous affiliations of Bryan R. Cullen include Hoffmann-La Roche & University of Medicine and Dentistry of New Jersey.
Papers
More filters
Journal ArticleDOI
RNA interference in human cells is restricted to the cytoplasm.
Yan Zeng,Bryan R. Cullen +1 more
TL;DR: The subcellular location at which RNA degradation occurs in human cells exposed to double-stranded short interfering RNAs is analyzed and suggests that RNAi is able to induce degradation of target mRNAs not only in the cytoplasm but also during the process of nuclear mRNA export.
Journal ArticleDOI
Regulation of HIV-1 gene expression.
TL;DR: This work has shown that the combination of Tat and Rev can stimulate a very high level of viral gene expression and replication in activated cells, and these same regulatory proteins are predicted to maintain the HIV‐1 provirus in a latent or nonproductive state.
Journal ArticleDOI
Viral MicroRNA Targetome of KSHV-Infected Primary Effusion Lymphoma Cell Lines
Eva Gottwein,David L. Corcoran,Neelanjan Mukherjee,Rebecca L. Skalsky,Markus Hafner,Markus Hafner,Jeffrey Nusbaum,Jeffrey Nusbaum,Priscilla Shamulailatpam,Cassandra Love,Sandeep S. Dave,Thomas Tuschl,Thomas Tuschl,Uwe Ohler,Bryan R. Cullen +14 more
TL;DR: It is shown that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function, which is likely to influence viral replication and pathogenesis.
Journal ArticleDOI
Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression.
Edward M. Kennedy,Hal P. Bogerd,Anand V.R. Kornepati,Dong Kang,Delta Ghoshal,Joy B. Marshall,Brigid Chiyoko Poling,Kevin Tsai,Nandan S. Gokhale,Stacy M. Horner,Bryan R. Cullen +10 more
TL;DR: photo-crosslinking-assisted m(6)A sequencing techniques are used to precisely map several m( 6)A editing sites on the HIV-1 genome and report that they cluster in the 3' untranslated region (3' UTR).
Journal ArticleDOI
Mutational definition of the human immunodeficiency virus type 1 Rev activation domain.
TL;DR: It is reported that the activation domain of Rev comprises a minimum of nine amino acids, four of which are critically spaced leucines, which suggests that the target for the activationdomain of Rev is likely to be a highly conserved cellular protein intrinsic to nuclear mRNA transport or splicing.