B
Bryan T. MacDonald
Researcher at Broad Institute
Publications - 43
Citations - 9992
Bryan T. MacDonald is an academic researcher from Broad Institute. The author has contributed to research in topics: Wnt signaling pathway & LRP6. The author has an hindex of 27, co-authored 41 publications receiving 8845 citations. Previous affiliations of Bryan T. MacDonald include Harvard University & Boston Children's Hospital.
Papers
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Journal ArticleDOI
Wnt/β-catenin signaling: components, mechanisms, and diseases
TL;DR: Some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis are highlighted, and potential therapeutic implications are discussed.
Journal ArticleDOI
Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2.
Andrew Escayg,Bryan T. MacDonald,Miriam H. Meisler,Stéphanie Baulac,Gilles Huberfeld,Isabelle An-Gourfinkel,Alexis Brice,Eric LeGuern,Bruno Moulard,Denys Chaigne,Catherine Buresi,Alain Malafosse +11 more
TL;DR: Two mutations of the gene encoding the neuronal voltage-gated sodium channel (SCN1A), Thr875Met and Arg1648His, that co-segregate with the disorder in two families with GEFS+ linked to chromosome 2q are described, identifying a new disease gene for human inherited epilepsy.
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Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.
Bryan T. MacDonald,Xi He +1 more
TL;DR: The current knowledge of Frizzled and LRP5/6 is reviewed, including their structures and interactions with Wnt proteins, and signaling mechanisms from receptor activation to the engagement of intracellular partners Dishevelled and Axin, and finally to the inhibition of β-catenin phosphorylation and ensuing β- catenin stabilization.
Journal ArticleDOI
Lrp5 functions in bone to regulate bone mass
Yajun Cui,Paul J. Niziolek,Paul J. Niziolek,Bryan T. MacDonald,Cassandra R. Zylstra,Natalia Alenina,Dan R. Robinson,Zhendong Zhong,Susann Matthes,Christina Jacobsen,Ronald A. Conlon,Robert Brommage,Qingyun Liu,Faika Mseeh,David R. Powell,Qi M. Yang,Brian Zambrowicz,Han Gerrits,Jan A. Gossen,Xi He,Michael Bader,Bart O. Williams,Matthew L. Warman,Alexander G. Robling +23 more
TL;DR: Data indicate that Lrp5 signaling functions locally, and they suggest that increasing LRP5 signaling in mature bone cells may be a strategy for treating human disorders associated with low bone mass, such as osteoporosis.
Journal ArticleDOI
SnapShot: Noncanonical Wnt Signaling Pathways.
TL;DR: Noncanonical Wnt signaling is defined here as Wnt- or Fz-initiated signaling that is independent of β-catenin transcriptional function.