Showing papers by "Byung Sun Min published in 2021"
TL;DR: Four new diterpene-type compounds normiltirone and isosalviamides F-H together with twelve known compounds were isolated from the roots of Salvia miltiorrhiza and evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.
20 citations
TL;DR: In this paper, 30 phloroglucinols (1−30) were isolated from a methanol extract of Dryopteris crassirhizoma, including two new dimeric compounds (13 and 25).
18 citations
TL;DR: In this article, the binding potential of the isolated compounds to highly conserved protein, Mpro of SARS-CoV-2 using the molecular docking technique was examined, and they found that the isolated saponins (14−17) bind to the substrate-binding pocket of Mpro.
12 citations
TL;DR: In this paper, the first report of the isolation and structure determination of broussonol I from a natural source was published, where the chemical structure of the undescribed compounds was determined using conventional NMR and HRMS data Absolute configurations were assigned using time-dependent density functional theory calculations and Electronic Circular Dichroism (ECD) spectroscopy.
5 citations
TL;DR: Results indicate that betulin-3β-yl-caffeate ( 5 ) may be a promising candidate for the treatment of osteoclast-related diseases such as osteoporosis.
Abstract: Fourteen triterpenes, lup-20(29)-ene-3β,6β-diol (1), betulin (2), lupeol caffeate (3), 3β-caffeoyloxylup-20(29)-en-6α-ol (4), betulin-3β-yl-caffeate (5), 3β-trans-feruloylbetulin (6), betulinaldehyde 3-caffeate (7), 3-O-trans-caffeoylbetulinic acid (8), dammarenediol II 3-caffeate (9), 12-oleanene-3β,6α-diol (10), 11α-hydroxy-3β-amyrin (11), nivadiol (12), 29-hydroxyfriedelin (13), and celastrusin A (14) were isolated from Celastrus orbiculatus Thunb. and evaluated for their activity on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in bone marrow macrophages (BMMs). Compounds betulin (2), betulin-3β-yl-caffeate (5), 3β-trans-feruloylbetulin (6), and 3-O-trans-caffeoylbetulinic acid (8) significantly inhibited osteoclast formation in a dose-dependent manner. Among these, betulin-3β-yl-caffeate (5) exhibited the most potent inhibitory activity. We demonstrated that betulin-3β-yl-caffeate (5) suppressed F-actin-ring formation and bone resorption activity. At the molecular level, betulin-3β-yl-caffeate (5) inhibited RANK-induced expression of c-Fos and the induction of nuclear factor of activated T cells 1 (NFATc1), a key transcription factor for osteoclast formation, and it also downregulated mRNA expression of osteogenesis-associated marker genes including tartrate-resistant acid phosphatase (TRAP), dendritic cell-specific transmembrane protein (DC-STAMP), and matrix metalloprotein (MMP). These results indicate that betulin-3β-yl-caffeate (5) may be a promising candidate for the treatment of osteoclast-related diseases such as osteoporosis.
5 citations
TL;DR: The white-flowered leaves of Eclipta prostrata L. together with leaves of Scoparia dulcis and Cynodon dactylon are mixedly boiled in water and given to diabetic patients resulting in the significant improvement in the management of diabetes as discussed by the authors.
Abstract: The white-flowered leaves of Eclipta prostrata L. together with leaves of Scoparia dulcis and Cynodon dactylon are mixedly boiled in water and given to diabetic patients resulting in the significant improvement in the management of diabetes. However, the active constituents from this plant for antidiabetic and anti-obesity properties are remaining unclear. Thus, this study was to discover anti-diabetes and anti-obesity activities through protein tyrosine phosphatases (PTP)1B inhibitory effects. We found that the fatty acids (23, 24) showed potent PTP1B inhibition with IC50 values of 2.14 and 3.21 µM, respectively. Triterpenoid-glycosides (12-15) also exhibited strong to moderate PTP1B inhibitory effects, with IC50 values ranging from 10.88 to 53.35 µM. Additionally, active compounds were investigated for their PTP1B inhibitory mechanism and docking analysis. On the other hand, the anti-inflammatory activity from our study revealed that compounds (1-4, 7, 8, 10) displayed the significant inhibition nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Especially, compound 9 showed the potent inhibitory effects in LPS-induced NO production on RAW264.7 cell. Therefore, further Western blot analysis was performed to identify the inhibitory expression including heme oxygenase-1 (HO-1) and inhibitor of kappaB (IκB) phosphorylation.
4 citations
TL;DR: In this paper, the authors showed that 3-methoxynobiletin (4) inhibited RANKL-induced c-Fos expression and subsequently NFATc1 activation, as well as the expression of osteoclastogenesis-related marker genes c-Src and CtsK.
3 citations
TL;DR: In this article, the alkaloid fraction of barley (Hordeum vulgare var. hexastichon) grass (HVA) significantly inhibited RANKL-induced osteoclast formation and protected mice from LPS-induced bone loss.
Abstract: As part of our continuous program to identify new potential candidates for controlling osteolytic bone diseases from natural products, the alkaloid fraction of barley (Hordeum vulgare var. hexastichon) grass (HVA) significantly inhibited RANKL-induced osteoclast formation and protected mice from LPS-induced bone loss. A phytochemical investigation of HVA afforded nine indole alkaloids, including one new compound [hordeumin A (1)] and eight known analogues (2-9). Of them, four (1, 2, 4, and 5) were anti-osteoclastogenic compounds. Of these four, compound 5 significantly suppressed RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner. It also suppressed the RANKL-induced NF-κB and MAPK signaling pathways and the activation of c-Fos and NFATc1. Compound 5 also reduced the expression levels of osteoclast-specific marker genes, including TRAP, CtsK, DC-STAMP, OSCAR, and MMP9. Our findings suggest that HVA and its alkaloid constituents could be valuable candidates for the prevention and treatment of osteolytic bone diseases.
2 citations
TL;DR: A new acetylene, (8S)-deca-4,6-diyne-1,8-di-O-β-D-glucopyranoside (4), and four known polyacetylenes (1,3 and 5), together with nine known flavonoids (6,14), were isolated from the flowers of Carthamus tinctorius L. as mentioned in this paper.
Abstract: A new acetylene, (8S)-deca-4,6-diyne-1,8-di-O-β-D-glucopyranoside (4), and four known polyacetylenes (1–3 and 5), together with nine known flavonoids (6–14), were isolated from the flowers of Carthamus tinctorius L. The structures of the isolates were elucidated by using spectroscopic analysis, mainly 1D and 2D NMR, HR-MS, and comparison with literature data, as well as enzymatic hydrolysis and Mosher′s esterification methods. All isolated compounds were evaluated for their anti-allergic effects by analyzing the inhibition of interleukin-2 (IL-2) expression in Jurkat T cells. Among them, 6-hydroxykaempferol 3,6-diglucoside (7) inhibited IL-2 production in activated T cells.
2 citations
TL;DR: Sixteen compounds, including six flavonoids (1–6), one lignan (7), three megastigmanes (8–10), three triterpenoids (11–13), and three benzoic acid derivatives (14–16) were isolated and structurally elucidated from the pseudo-fruits of Hovenia dulcis, revealing a relationship between H. dULcis and H. acerbar.
1 citations