Journal ArticleDOI
Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity.
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TLDR
Four new diterpene-type compounds normiltirone and isosalviamides F-H together with twelve known compounds were isolated from the roots of Salvia miltiorrhiza and evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.About:
This article is published in Natural Product Research.The article was published on 2021-03-01. It has received 20 citations till now. The article focuses on the topics: Salvia miltiorrhiza.read more
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CRISPR/Cas genome editing to optimize pharmacologically active plant natural products.
TL;DR: This genome-editing tool further extends its applicability incorporating the tools of synthetic- and systems-biology, functional-genomics and NGS to produce genetically-engineered medicinal-crops with advanced-traits facilitating the production of pharmaceuticals and nutraceuticals.
Journal ArticleDOI
Antiproliferative abietane quinone diterpenoids from the roots of Salvia deserta.
Xiaofeng Zheng,Abdukriem Kadir,Guijuan Zheng,Pengfei Jin,Dongmei Qin,Maitinuer Maiwulanjiang,Haji Akber Aisa,Guangmin Yao +7 more
TL;DR: Abietane quinone diterpenoids 1, 2, and 4-20 were evaluated for their antiproliferative activities against five cancer cell lines A-549, SMMC-7721, SW480, MCF-7, and HL-60 and a normal epithelial cell line BEAS-2B in vitro.
Journal ArticleDOI
Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery.
Jiamin Ge,Zhen Liu,Zhichao Zhong,Li-Wei Wang,Xiao-Tao Zhuo,Junjie Li,Xiao-nan Jiang,Xiang-Yang Ye,Tian Xie,Renren Bai +9 more
TL;DR: In this article , the authors reviewed the chemical structures, anti-inflammatory activities, and mechanisms of action of 281 terpenoid natural products reported from 2010 to the present, and both in vitro and in vivo screening models were also surveyed and statistically summarized.
Journal ArticleDOI
Biosynthesis and Regulatory Mechanisms of Bioactive Compounds in Salvia miltiorrhiza, a Model System for Medicinal Plant Biology
TL;DR: Salvia miltiorrhiza is one of the most well known species in the genus Salvia of the Lamiaceae with great economic, academic and medicinal value.
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The Anti-Inflammatory and the Antinociceptive Effects of Mixed Agrimonia pilosa Ledeb. and Salvia miltiorrhiza Bunge Extract.
Jing-Hui Feng,Hyun-Yong Kim,Su-Min Sim,Guanglei Zuo,Jeon-Sub Jung,Seung-Hwan Hwang,Youn-Gil Kwak,Min-Jung Kim,Jeong-Hun Jo,Sung Chan Kim,Soon Sung Lim,Hong-Won Suh +11 more
TL;DR: In this paper, the anti-inflammatory and antinociceptive effects of mixture extract (ME) from Agrimonia pilosa Ledeb and Salvia miltiorrhiza Bunge (SM) could ameliorate gout arthritis.
References
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Journal ArticleDOI
New developments in the chemistry and biology of the bioactive constituents of Tanshen.
TL;DR: This review will focus on recent developments concerning the chemical constituents of Tanshen and their biological activities and a new compound, neo‐tanshinlactone, was discovered to have potent selective antibreast cancer activity.
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Constituents from Salvia species and their biological activities.
TL;DR: This paper aims to provide a history of forensic medicine in China and its applications in the field of regenerative medicine, as well as some examples of how modern forensic medicine has changed over time.
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Salvia miltiorrhiza: Traditional medicinal uses, chemistry, and pharmacology.
TL;DR: The research results strongly support the notion that SM has beneficial therapeutic properties and has a potential of being an effective adaptogenic remedy.
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Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells.
Seon-Il Jang,Seung-Il Jeong,Kang-Ju Kim,Hyungjin Kim,Hyeon-Hee Yu,Raekil Park,Hyung-Min Kim,Yong-Ouk You +7 more
TL;DR: The results suggest that the traditional use of S. miltiorrhiza as an anti-inflammatory herbal medicine may be explained, in part, by the inhibition of NO, IL-1beta,IL-6 and TNF-alpha production, and expression of iNOS.
Journal ArticleDOI
Salvia miltiorrhiza: Chemical and pharmacological review of a medicinal plant
TL;DR: The aim of this review is to up-date and to present a comprehensive analysis of traditional uses, pharmacological reports and phyto-constituents isolated from the plant.