C. Naltet

TL;DR: It is found that primary resistance to ICIs can be attributed to abnormal gut microbiome composition, and Antibiotics inhibited the clinical benefit of ICIs in patients with advanced cancer.

TL;DR: This study shows that mechanisms of resistance to lorlatinib are diverse and complex, requiring new therapeutic strategies to tailor treatment upon disease progression, and identifies a novel bypass mechanism of resistance caused by NF2 loss-of-function mutations, conferring sensitivity to treatment with mTOR inhibitors.

TL;DR: Although tagged amplicon-based NGS has high detection rates of GA in plasma ctDNA in NSCLC patients with extraCNS disease, detection rate of GAs is lower in the subset of iCNS patients, suggesting complementary tests, such as CSF cell-free DNA, may be useful.

TL;DR: A case of lung sarcomatoid carcinoma with Nivolumab dramatic and long-lasting efficacy, but occurrence of a very specific pattern of lung toxicity, the so-called 'organizing bronchiolitis syndrome' is reported.