Caitlin F Fowler

TL;DR: This is the first MRI atlas created using Fischer 344 rats and will thus provide an appropriate neuroanatomical model for researchers working with this strain, according to the knowledge.

TL;DR: In this paper, the authors reported the simultaneous absolute quantification of brain metabolites and individual macromolecules in aging male and female Fischer 344 rats, measured longitudinally using proton magnetic resonance spectroscopy at 7 T.

TL;DR: StandardRat is introduced, a consensus rat functional MRI acquisition protocol that enhances biologically plausible functional connectivity patterns, relative to pre-existing acquisitions, and is openly shared with the neuroimaging community to promote interoperability and cooperation towards tackling the most important challenges in neuroscience.

TL;DR: StandardRat as mentioned in this paper is a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers and showed that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions, and is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

TL;DR: Findings support the use of MRI and magnetic resonance spectroscopy for the development of non-invasive biomarkers of disease progression, clarify the timing of pathological feature presentation in this model, and contribute to the validation of the TgF344-AD rat as a highly relevant model for pre-clinical Alzheimer’s disease research.