C
Cara Woodwark
Researcher at Wellcome Trust Sanger Institute
Publications - 4
Citations - 4377
Cara Woodwark is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Copy-number variation & Single-nucleotide polymorphism. The author has an hindex of 4, co-authored 4 publications receiving 4200 citations.
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Journal ArticleDOI
Global variation in copy number in the human genome
Richard Redon,Shumpei Ishikawa,Karen R. Fitch,Lars Feuk,George H. Perry,T. Daniel Andrews,Heike Fiegler,Michael H. Shapero,Andrew R. Carson,Wenwei Chen,Eun Kyung Cho,Stephanie Dallaire,Jennifer L. Freeman,Juan R. González,Mònica Gratacòs,Jing Huang,Dimitrios Kalaitzopoulos,Daisuke Komura,Jeffrey R. MacDonald,Christian R. Marshall,Rui Mei,Lyndal Montgomery,Keunihiro Nishimura,Kohji Okamura,Fan Shen,Martin J. Somerville,Joelle Tchinda,Armand Valsesia,Cara Woodwark,Fengtang Yang,Junjun Zhang,Tatiana Zerjal,Jane Zhang,Lluís Armengol,Donald F. Conrad,Xavier Estivill,Chris Tyler-Smith,Nigel P. Carter,Hiroyuki Aburatani,Charles Lee,Keith W. Jones,Stephen W. Scherer,Matthew E. Hurles +42 more
TL;DR: A first-generation CNV map of the human genome is constructed through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia, underscoring the importance of CNV in genetic diversity and evolution and the utility of this resource for genetic disease studies.
Journal ArticleDOI
Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation
Yali Xue,Xuelong Zhang,Xuelong Zhang,Ni Huang,Allan Daly,Christopher J. Gillson,Daniel G. MacArthur,Bryndis Yngvadottir,Alexandra C. Nica,Cara Woodwark,Yuan Chen,Donald F. Conrad,Qasim Ayub,S. Qasim Mehdi,Pu Li,Chris Tyler-Smith +15 more
TL;DR: In humans, high population differentiation is an effective way of enriching for recently selected genes, but is not an infallible pointer to recent positive selection supported by other lines of evidence.
Journal ArticleDOI
The Characterisation of Three Types of Genes that Overlie Copy Number Variable Regions
Cara Woodwark,Alex Bateman +1 more
TL;DR: Looking into possible mechanisms for the regulation of gene expression, it is found that type I genes have a significant paucity of genes regulated by miRNAs and are not significantly enriched for monoallelically expressed genes.
Journal ArticleDOI
Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing
Johanna Maria de Gruijter,Johanna Maria de Gruijter,Oscar Lao,Mark Vermeulen,Yali Xue,Cara Woodwark,Christopher J. Gillson,Alison J. Coffey,Qasim Ayub,S. Qasim Mehdi,Manfred Kayser,Chris Tyler-Smith +11 more
TL;DR: The data indicate that even genes that are strong biological candidates for positive selection and show reproducible signatures of positive selection in SNP scans do not always show the same replicability of selection signals in other tests, which should be considered in future studies on detectingpositive selection in genetic data.