Carla Luzi

TL;DR: This work investigates the antibacterial, haemolytic and cytotoxic activities of temporin L (FVQWFSKFLGRIL-NH2), isolated from the skin of the European red frog Rana temporaria, which displayed the highest activity of temporins studied to date, against both human erythrocytes and bacterial and fungal strains.

TL;DR: The activity of temporin L when combined with imipenem and piperacillin in the prevention of lethality in two rat models of septic shock is characterized, measuring bacterial growth in blood and intra-abdominal fluid, endotoxin and tumor necrosis factor alpha concentrations in plasma, and lethality.

TL;DR: CeO2 NPs increases the effectiveness of antimicrobials which activity is compromised by drug resistance mechanisms and the synergistic effect is the result of the interaction of NPs with the bacterial outer membrane.

TL;DR: Investigation of the in vitro effects of resveratrol on apoptotic pathway in human chronic myeloid and acute lymphoblastic leukemia cells indicated that RES commitment to apoptosis in both cell lines is independent from the intracellular content of glutathione, while it is associated with either the enhanced expression of Bax and cytochrome c release.

TL;DR: The data obtained in the present study using different approaches strongly suggest that the ability of hepcidins to perturb bacterial membranes is markedly pH‐dependent.