Carol DeWeese-Scott

TL;DR: NCBI’s Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from these footprints.

TL;DR: The progress of the curation effort and associated improvements in the functionality of the CDD information retrieval system are reported on.

TL;DR: NCBI's Conserved Domain Database is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution, and provides annotation of domain footprints and conserved functional sites on protein sequences.

TL;DR: A novel helper application, CDTree, is presented, which enables users of the CDD resource to examine curated hierarchies and serve as a powerful tool in protein classification, as they allow users to analyze protein sequences in the context of domain family hierarchies.

TL;DR: The Conserved Domain Database (CDD), which mirrors the publicly available domain alignment collections SMART and PFAM, and now also contains alignment models curated at NCBI, is now indexed as a separate database within the Entrez system and linked to other Entrez databases such as MEDLINE(R).