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Carole Elbim
Researcher at University of Paris
Publications - 84
Citations - 5753
Carole Elbim is an academic researcher from University of Paris. The author has contributed to research in topics: Respiratory burst & Proinflammatory cytokine. The author has an hindex of 42, co-authored 82 publications receiving 5157 citations. Previous affiliations of Carole Elbim include Paris Descartes University & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
NAD(P)H Oxidase Nox-4 Mediates 7-Ketocholesterol-Induced Endoplasmic Reticulum Stress and Apoptosis in Human Aortic Smooth Muscle Cells
Eric Pedruzzi,Cécile Guichard,Véronique Ollivier,Fathi Driss,Michèle Fay,Céline Prunet,Jean-Claude Marie,Cécile Pouzet,Mohammad Samadi,Carole Elbim,Yvonne O'Dowd,Marcelle Bens,Alain Vandewalle,Marie-Anne Gougerot-Pocidalo,Gérard Lizard,Eric Ogier-Denis +15 more
TL;DR: It is shown that 7-ketocholesterol (7-Kchol) induces oxidative stress and/or apoptotic events in human aortic smooth muscle cells (SMCs), which is consistent with the hypothesis that Nox-4/oxysterols are involved in the pathogenesis of atherosclerosis.
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Tissue damage from neutrophil-induced oxidative stress in COVID-19.
Mireille Laforge,Carole Elbim,Corinne Frere,Miryana Hémadi,Charbel Massaad,Philippe Nuss,Jean-Jacques Benoliel,Chrystel Becker +7 more
TL;DR: It is suggested that free radical scavengers could be beneficial for the most vulnerable patients with COVID-19, because of how the excessive release of reactive oxygen species by neutrophils may perpetuate red blood cell dysfunction, thrombosis and tissue damage in severe cases of COIDs.
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Hydroxyl Radical as a Potential Intracellular Mediator of Polymorphonuclear Neutrophil Apoptosis
Emmanuelle Rollet-Labelle,Marie-José Grange,Carole Elbim,Claude Marquetty,Marie-Anne Gougerot-Pocidalo,Catherine Pasquier +5 more
TL;DR: It is observed that two iron chelators, deferoxamine and hydroxybenzyl ethylenediamine (HBED), both inhibited spontaneous and accelerated apoptosis, suggesting that HO may mediate neutrophil apoptosis.
Journal ArticleDOI
Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS.
Sylvie Chollet-Martin,Beatrice Jourdain,Claude Gibert,Carole Elbim,Jean Chastre,Marie Anne Gougerot-Pocidalo +5 more
TL;DR: It is found that ARDS-associated lung injury could be caused, at least in part, by inappropriate adhesion and transendothelial migration of proinflammatory cytokine-primed PMN.
Journal ArticleDOI
Inhibition of Neutrophil Apoptosis by TLR Agonists in Whole Blood: Involvement of the Phosphoinositide 3-Kinase/Akt and NF-κB Signaling Pathways, Leading to Increased Levels of Mcl-1, A1, and Phosphorylated Bad
Stephanie François,Jamel El Benna,Pham My-Chan Dang,Eric Pedruzzi,Marie-Anne Gougerot-Pocidalo,Carole Elbim +5 more
TL;DR: The results strongly suggest a role of NF-κB and PI3K in TLR-induced PMN survival, leading to modulation of Bcl-2 family molecules.