Cécile Guichard

TL;DR: Functional analyses showed tumor suppressor properties for IRF2, whose inactivation, exclusively found in hepatitis B virus-related tumors, led to impaired TP53 function, and association of mutations in specific genes suggested that Wnt/β-catenin signaling might cooperate in liver carcinogenesis with both oxidative stress metabolism and Ras/mitogen-activated protein kinase (MAPK) pathways.

TL;DR: It is shown that 7-ketocholesterol (7-Kchol) induces oxidative stress and/or apoptotic events in human aortic smooth muscle cells (SMCs), which is consistent with the hypothesis that Nox-4/oxysterols are involved in the pathogenesis of atherosclerosis.

TL;DR: This study supports miRNAs as crucial players in the onset and/or relapse of inflammation from quiescent mucosal tissues in IBD patients and suggests that some of the miRNA with altered expression in the quiescence mucosa of I BD patients may define miRNA signatures for UC and CD and help develop new diagnostic biomarkers.

TL;DR: It is demonstrated that in lungs of patients with idiopathic lung fibrosis, there is strong expression of NOX4 in hyperplastic alveolar type II cells, and ROS generation by Nox4 is a key player in epithelial cell death leading to pulmonary fibrosis.

TL;DR: A new version of the grapevine reference genome assembly and of its annotation and its VCost.v3 gene annotation in Genbank format is presented.