C
Carole Lartigue
Researcher at Institut national de la recherche agronomique
Publications - 46
Citations - 3975
Carole Lartigue is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 19, co-authored 37 publications receiving 3511 citations. Previous affiliations of Carole Lartigue include University of Bordeaux & J. Craig Venter Institute.
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Journal ArticleDOI
Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome
Daniel G. Gibson,John I. Glass,Carole Lartigue,Vladimir N. Noskov,Ray-Yuan Chuang,Mikkel A. Algire,Gwynedd A. Benders,Michael G. Montague,Li Ma,Monzia Moodie,Chuck Merryman,Sanjay Vashee,Radha Krishnakumar,Nacyra Assad-Garcia,Cynthia Andrews-Pfannkoch,Evgeniya A. Denisova,Lei Young,Zhi-Qing Qi,Thomas H. Segall-Shapiro,Christopher H. Calvey,Prashanth P. Parmar,Clyde A. Hutchison,Hamilton O. Smith,J. Craig Venter +23 more
TL;DR: The design, synthesis, and assembly of the 1.08–mega–base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new cells that are controlled only by the synthetic chromosome are reported.
Journal ArticleDOI
Genome transplantation in bacteria: changing one species to another.
Carole Lartigue,John I. Glass,Nina Alperovich,Rembert Pieper,Prashanth P. Parmar,Clyde A. Hutchison,Hamilton O. Smith,J. Craig Venter +7 more
TL;DR: This work completely replaced the genome of a bacterial cell with one from another species by transplanting a whole genome as naked DNA into Mycoplasma capricolum cells by polyethylene glycol–mediated transformation.
Journal ArticleDOI
Creating bacterial strains from genomes that have been cloned and engineered in yeast.
Carole Lartigue,Sanjay Vashee,Mikkel A. Algire,Ray-Yuan Chuang,Gwynedd A. Benders,Li Ma,Vladimir N. Noskov,Evgeniya A. Denisova,Daniel G. Gibson,Nacyra Assad-Garcia,Nina Alperovich,David W. Thomas,Chuck Merryman,Clyde A. Hutchison,Hamilton O. Smith,J. Craig Venter,John I. Glass +16 more
TL;DR: Methods to accomplish the construction of strains that could not be produced with genetic tools available for this bacterium, including the chemical synthesis, assembly, and cloning of a bacterial genome in yeast, are described.
Journal ArticleDOI
Being pathogenic, plastic, and sexual while living with a nearly minimal bacterial genome
Pascal Sirand-Pugnet,Carole Lartigue,Carole Lartigue,Marc S. Marenda,Daniel J. Jacob,Aurélien Barré,Valérie Barbe,Chantal Schenowitz,Sophie Mangenot,Arnaud Couloux,Béatrice Segurens,Antoine de Daruvar,Alain Blanchard,Alain Blanchard,Christine Citti +14 more
TL;DR: This first description of large-scale HGT among mycoplasmas sharing the same ecological niche challenges the generally accepted evolutionary scenario in which gene loss is the main driving force of myCoplasma evolution.
Journal ArticleDOI
Cloning whole bacterial genomes in yeast
Gwynedd A. Benders,Vladimir N. Noskov,Evgeniya A. Denisova,Carole Lartigue,Daniel G. Gibson,Nacyra Assad-Garcia,Ray-Yuan Chuang,William Carrera,Monzia Moodie,Mikkel A. Algire,Quang Phan,Nina Alperovich,Sanjay Vashee,Chuck Merryman,J. Craig Venter,Hamilton O. Smith,John I. Glass,Clyde A. Hutchison +17 more
TL;DR: The cloning of whole bacterial genomes in the yeast Saccharomyces cerevisiae as single-DNA molecules is reported, and these genomes appear to be stably maintained in a host that has efficient, well-established methods for DNA manipulation.