Carolyn K. Dong

TL;DR: A large study of in vivo expression profiles of parasites derived directly from blood samples from infected patients reveals a previously unknown physiological diversity in the in vivo biology of the malaria parasite, and indicates in vivo and in vitro studies to determine how this variation may affect disease manifestations and treatment.

TL;DR: Investigation of the structure activity relationship within this previously unexplored chemical scaffold has yielded inhibitors with low nanomolar activity, and intriguingly, BTZ-based inhibitors retain activity against atovaquone resistant parasites, suggesting this chemical class may provide an alternative to atovaquin in combination therapy.

TL;DR: Evidence that HDQ likely targets another P. falciparum mitochondrial enzyme, dihydroorotate dehydrogenase (pfDHOD), which is essential for de novo pyrimidine biosynthesis is provided.

TL;DR: Both the bioinformatic and functional data reported here imply that multiple forms of gene regulation, including post-transcriptional control, may be important in the malarial system.