Carolyn Marks

TL;DR: The results indicate that eNOS activity is up-regulated in Cav-1 null animals, and this activity can be blunted by using a specific NOS inhibitor, nitro-l-arginine methyl ester.

TL;DR: The primary attenuating mechanism of bacillus Calmette–Guérin is the loss of cytolytic activity mediated by secreted ESAT-6, which results in reduced tissue invasiveness.

TL;DR: It is shown that virus binding to filopodia induces a rapid and highly ordered lateral movement, “surfing” toward the cell body before cell entry, which significantly reduces viral infection.

TL;DR: It is found that the PrgJ-NAIP2-NLRC4 inflammasome is assembled into multisubunit disk-like structures through a unidirectional adenosine triphosphatase polymerization, primed with a single PrGJ-activated NAIP2 per disk.

TL;DR: It is shown that embryonic fibroblasts from Syt VII–deficient mice are less susceptible to trypanosome invasion, and defective in lysosomal exocytosis and resealing after wounding, which suggests defective plasma membrane repair in tissues under mechanical stress may favor the development of inflammatory autoimmune disease.