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Alvin Lu
Researcher at Harvard University
Publications - 27
Citations - 2630
Alvin Lu is an academic researcher from Harvard University. The author has contributed to research in topics: Inflammasome & Pyrin domain. The author has an hindex of 16, co-authored 25 publications receiving 1946 citations. Previous affiliations of Alvin Lu include Boston Children's Hospital.
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Journal ArticleDOI
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
Alvin Lu,Venkat Giri Magupalli,Venkat Giri Magupalli,Jianbin Ruan,Jianbin Ruan,Qian Yin,Qian Yin,Maninjay K. Atianand,Matthijn R. J. Vos,Gunnar F. Schröder,Katherine A. Fitzgerald,Hao Wu,Hao Wu,Edward H. Egelman +13 more
TL;DR: It is proposed that ASC-dependent inflammasomes in both families share a unified assembly mechanism that involves two successive steps of nucleation-induced polymerization.
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Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Liman Zhang,Shuobing Chen,Jianbin Ruan,Jianbin Ruan,Jiayi Wu,Jiayi Wu,Alexander B. Tong,Alexander B. Tong,Qian Yin,Qian Yin,Yang Li,Yang Li,Liron David,Liron David,Alvin Lu,Alvin Lu,Wei Li Wang,Carolyn Marks,Qi Ouyang,Xinzheng Zhang,Youdong Mao,Youdong Mao,Hao Wu,Hao Wu +23 more
TL;DR: It is found that the PrgJ-NAIP2-NLRC4 inflammasome is assembled into multisubunit disk-like structures through a unidirectional adenosine triphosphatase polymerization, primed with a single PrGJ-activated NAIP2 per disk.
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Structural mechanisms of inflammasome assembly
TL;DR: Current understandings of the structures of inflammasomes, as probed using traditional structural methods, as well as biochemical, biophysical and single‐molecule methods, suggest that Pyrin domain and CARD filaments possess prion‐like properties in propagating inflammaome activation within and between cells.
Journal ArticleDOI
A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly
Florian I. Schmidt,Alvin Lu,Alvin Lu,Jeff Chen,Jianbin Ruan,Jianbin Ruan,Catherine Tang,Catherine Tang,Hao Wu,Hao Wu,Hidde L. Ploegh +10 more
TL;DR: Alpaca single-domain antibody VHHASC blocks inflammasome activation in vitro and in living cells, and demonstrates a role of the ASC CARD domain in cross-linking ASC Pyrin domain filaments.
Journal ArticleDOI
Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex
Tian-Min Fu,Yang Li,Yang Li,Alvin Lu,Alvin Lu,Zongli Li,Parimala R. Vajjhala,Anthony C. Cruz,Devendra B. Srivastava,Devendra B. Srivastava,Frank DiMaio,Pawel A. Penczek,Richard M. Siegel,Katryn J. Stacey,Edward H. Egelman,Hao Wu,Hao Wu +16 more
TL;DR: Using the tDED filament structure as a template, structural analyses reveal the interaction surfaces between FADD and caspase-8 and the distinct mechanisms of regulation by cFLIP and MC159 through comingling and capping, respectively.