Harry Hou

TL;DR: The results indicate that eNOS activity is up-regulated in Cav-1 null animals, and this activity can be blunted by using a specific NOS inhibitor, nitro-l-arginine methyl ester.

TL;DR: The identification of the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1) provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.

TL;DR: Mice lacking the imprinted Cdk inhibitor p57KIP2 have altered cell proliferation and differentiation, leading to abdominal muscle defects; cleft palate; endochondral bone ossification defects with incomplete differentiation of hypertrophic chondrocytes; renal medullary dysplasia; adrenal cortical hyperplasia and cytomegaly; and lens cell hyperproliferation and apoptosis.

TL;DR: Somatic loss of Pkd2 expression is both necessary and sufficient for renal cyst formation in ADPKD, suggesting that PKD2 occurs by a cellular recessive mechanism.

TL;DR: Analysis of skeletal muscle tissue from these caveolin-3 null mice reveals mild myopathic changes; an exclusion of the dystrophin-glycoprotein complex from lipid raft domains; and abnormalities in the organization of the T- Tubule system, with dilated and longitudinally oriented T-tubules.