C
Carolyn Marquis
Researcher at University of Vermont
Publications - 4
Citations - 165
Carolyn Marquis is an academic researcher from University of Vermont. The author has contributed to research in topics: Mitosis & Multipolar spindles. The author has an hindex of 4, co-authored 4 publications receiving 50 citations.
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Journal ArticleDOI
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition
Yael Cohen-Sharir,James M. McFarland,Mai Abdusamad,Carolyn Marquis,Sara Vanessa Bernhard,Mariya Kazachkova,Helen Tang,Marica Rosaria Ippolito,Kathrin Laue,Johanna Zerbib,Heidi L.H. Malaby,Andrew Jones,Lisa-Marie Stautmeister,Irena Bockaj,René Wardenaar,Nicholas J. Lyons,Ankur K. Nagaraja,Ankur K. Nagaraja,Adam J. Bass,Adam J. Bass,Diana C.J. Spierings,Floris Foijer,Rameen Beroukhim,Rameen Beroukhim,Stefano Santaguida,Stefano Santaguida,Todd R. Golub,Todd R. Golub,Jason Stumpff,Zuzana Storchova,Uri Ben-David +30 more
TL;DR: In this paper, aneuploid cancer cells exhibited aberrant spindle geometry and dynamics, and kept dividing when the SAC was inhibited, resulting in the accumulation of mitotic defects, and in unstable and less-fit karyotypes.
Journal ArticleDOI
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Carolyn Marquis,Cindy L. Fonseca,Katelyn A. Queen,Lisa Wood,Sarah E. Vandal,Heidi L.H. Malaby,Joseph E. Clayton,Jason Stumpff +7 more
TL;DR: In this article, a subset of kinesin motor proteins involved in mitotic spindle control was inhibited, and the effect of the inhibition on the spindle microtubule dynamics was investigated.
Posted ContentDOI
Chromosomally unstable tumor cells specifically require KIF18A for proliferation
Carolyn Marquis,Cindy L. Fonseca,Katelyn A. Queen,Lisa Wood,Sarah E. Vandal,Heidi L.H. Malaby,Joseph E. Clayton,Jason Stumpff +7 more
TL;DR: The results indicated that KIF18A was required for proliferation of CIN cells derived from triple negative breast cancer or colorectal cancer tumors but was not required in near-diploid cells.
Posted ContentDOI
Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint
Yael Cohen-Sharir,James M. McFarland,Mai Abdusamad,Carolyn Marquis,Helen Tang,Marica Rosaria Ippolito,Sara Vanessa Bernhard,Kathrin Laue,Heidi L.H. Malaby,Andrew Jones,Mariya Kazachkova,Nicholas J. Lyons,Ankur K. Nagaraja,Ankur K. Nagaraja,Adam J. Bass,Adam J. Bass,Rameen Beroukhim,Rameen Beroukhim,Stefano Santaguida,Stefano Santaguida,Jason Stumpff,Todd R. Golub,Todd R. Golub,Zuzana Storchova,Uri Ben-David +24 more
TL;DR: A novel synthetic lethal interaction between aneuploidy and the SAC, which may have direct therapeutic relevance for the clinical application of SAC inhibitors is revealed and its cellular and molecular underpinnings are explored.