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Yael Cohen-Sharir
Researcher at Tel Aviv University
Publications - 5
Citations - 107
Yael Cohen-Sharir is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Aneuploidy & Spindle checkpoint. The author has an hindex of 2, co-authored 3 publications receiving 33 citations.
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Journal ArticleDOI
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition
Yael Cohen-Sharir,James M. McFarland,Mai Abdusamad,Carolyn Marquis,Sara Vanessa Bernhard,Mariya Kazachkova,Helen Tang,Marica Rosaria Ippolito,Kathrin Laue,Johanna Zerbib,Heidi L.H. Malaby,Andrew Jones,Lisa-Marie Stautmeister,Irena Bockaj,René Wardenaar,Nicholas J. Lyons,Ankur K. Nagaraja,Ankur K. Nagaraja,Adam J. Bass,Adam J. Bass,Diana C.J. Spierings,Floris Foijer,Rameen Beroukhim,Rameen Beroukhim,Stefano Santaguida,Stefano Santaguida,Todd R. Golub,Todd R. Golub,Jason Stumpff,Zuzana Storchova,Uri Ben-David +30 more
TL;DR: In this paper, aneuploid cancer cells exhibited aberrant spindle geometry and dynamics, and kept dividing when the SAC was inhibited, resulting in the accumulation of mitotic defects, and in unstable and less-fit karyotypes.
Posted ContentDOI
Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint
Yael Cohen-Sharir,James M. McFarland,Mai Abdusamad,Carolyn Marquis,Helen Tang,Marica Rosaria Ippolito,Sara Vanessa Bernhard,Kathrin Laue,Heidi L.H. Malaby,Andrew Jones,Mariya Kazachkova,Nicholas J. Lyons,Ankur K. Nagaraja,Ankur K. Nagaraja,Adam J. Bass,Adam J. Bass,Rameen Beroukhim,Rameen Beroukhim,Stefano Santaguida,Stefano Santaguida,Jason Stumpff,Todd R. Golub,Todd R. Golub,Zuzana Storchova,Uri Ben-David +24 more
TL;DR: A novel synthetic lethal interaction between aneuploidy and the SAC, which may have direct therapeutic relevance for the clinical application of SAC inhibitors is revealed and its cellular and molecular underpinnings are explored.
Posted ContentDOI
Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage
Johanna Zerbib,Marica Rosaria Ippolito,Yonatan Eliezer,Giuseppina De Feudis,Eli Reuveni,Anouk Savir Kadmon,Sara Martin,S. Vigano,Gil Leor,James Berstler,Kathrin Laue,Yael Cohen-Sharir,Simone Scorzoni,Francisca Vazquez,Uri Ben-David,Stefano Santaguida +15 more
TL;DR: In this paper , aneuploidy was induced in non-transformed RPE1-hTERT cells and derived multiple stable clones with various degrees of chromosome imbalances.
Journal ArticleDOI
Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A.
Yael Cohen-Sharir,Uri Ben-David +1 more
TL;DR: Aneuploidy, a common feature of cancer cells, results in increased sensitivity to the inhibition of the spindle assembly checkpoint (SAC) and the mitotic motor protein Kinesin Family Member 18A (KIF18A) as discussed by the authors.
Posted ContentDOI
Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells
Marica Rosaria Ippolito,Johanna Zerbib,Yonatan Eliezer,Eli Reuveni,S. Vigano,Giuseppina De Feudis,Anouk Savir Kadmon,Ilaria Vigorito,Sara Martin,Kathrin Laue,Yael Cohen-Sharir,Simone Scorzoni,Francisca Vazquez,Stefano Santaguida,Uri Ben-David +14 more
TL;DR: In this paper , the authors investigated the role of aneuploidy in dosage compensation in human cancer cells and found that anneuploid cells cope with both transcriptional burden and proteotoxic stress by regulating their RNA and protein levels.