M
Mariya Kazachkova
Researcher at Broad Institute
Publications - 8
Citations - 363
Mariya Kazachkova is an academic researcher from Broad Institute. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 3, co-authored 4 publications receiving 176 citations.
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Posted ContentDOI
Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines
Joshua M. Dempster,Jordan Rossen,Mariya Kazachkova,Joshua Pan,Guillaume Kugener,David E. Root,Aviad Tsherniak +6 more
TL;DR: The current and projected Achilles processing pipeline, including recent improvements and the analyses that led us to adopt them, are presented, spanning data releases from early 2018 to the first quarter of 2020.
Journal ArticleDOI
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition
Yael Cohen-Sharir,James M. McFarland,Mai Abdusamad,Carolyn Marquis,Sara Vanessa Bernhard,Mariya Kazachkova,Helen Tang,Marica Rosaria Ippolito,Kathrin Laue,Johanna Zerbib,Heidi L.H. Malaby,Andrew Jones,Lisa-Marie Stautmeister,Irena Bockaj,René Wardenaar,Nicholas J. Lyons,Ankur K. Nagaraja,Ankur K. Nagaraja,Adam J. Bass,Adam J. Bass,Diana C.J. Spierings,Floris Foijer,Rameen Beroukhim,Rameen Beroukhim,Stefano Santaguida,Stefano Santaguida,Todd R. Golub,Todd R. Golub,Jason Stumpff,Zuzana Storchova,Uri Ben-David +30 more
TL;DR: In this paper, aneuploid cancer cells exhibited aberrant spindle geometry and dynamics, and kept dividing when the SAC was inhibited, resulting in the accumulation of mitotic defects, and in unstable and less-fit karyotypes.
Posted ContentDOI
Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer
Daniel P. Bondeson,Brenton R. Paolella,Adhana Asfaw,Michael V. Rothberg,Thomas A. Skipper,Carly Langan,Alfredo Gonzalez,Lauren E. Surface,Kentaro Ito,Mariya Kazachkova,William Colgan,Allison Warren,Josh Dempster,Mike Burger,Maria Ericsson,Andrew Tang,Iris Fung,Emily Chambers,Mai Abdusamad,Nancy Dumont,John G. Doench,Federica Piccioni,David E. Root,Jesse S. Boehm,William C. Hahn,William C. Hahn,Michael Mannstadt,James M. McFarland,Francisca Vazquez,Todd R. Golub,Todd R. Golub +30 more
TL;DR: All data point to the XPR1:KIDINS220 complex - and phosphate dysregulation more broadly - as a therapeutic vulnerability in ovarian cancer.
Posted ContentDOI
Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint
Yael Cohen-Sharir,James M. McFarland,Mai Abdusamad,Carolyn Marquis,Helen Tang,Marica Rosaria Ippolito,Sara Vanessa Bernhard,Kathrin Laue,Heidi L.H. Malaby,Andrew Jones,Mariya Kazachkova,Nicholas J. Lyons,Ankur K. Nagaraja,Ankur K. Nagaraja,Adam J. Bass,Adam J. Bass,Rameen Beroukhim,Rameen Beroukhim,Stefano Santaguida,Stefano Santaguida,Jason Stumpff,Todd R. Golub,Todd R. Golub,Zuzana Storchova,Uri Ben-David +24 more
TL;DR: A novel synthetic lethal interaction between aneuploidy and the SAC, which may have direct therapeutic relevance for the clinical application of SAC inhibitors is revealed and its cellular and molecular underpinnings are explored.
Journal ArticleDOI
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas
Lisa D. Cervia,Tsukasa Shibue,Ashir A. Borah,Benjamin Gaeta,Lin-Juan He,Lisa H. Leung,Na Li,Sydney M. Moyer,Brian H Shim,Nancy Dumont,Alfredo Gonzalez,Mariya Kazachkova,Joshua M. Dempster,John M. Krill-Burger,Federica Piccioni,Namrata D. Udeshi,Meagan E. Olive,Steven A. Carr,David E. Root,James M. McFarland,Francisca Vazquez,William C. Hahn +21 more
TL;DR: It is found that a ubiquitination ligase complex composed of UBA6, BIRC6, KCMF1 and UBR4, which encode an E1, E2 and two heterodimeric E3 subunits is required for the survival of a subset of epithelial tumors, particularly subtypes of breast cancer.