Johanna Zerbib

TL;DR: In this paper, aneuploid cancer cells exhibited aberrant spindle geometry and dynamics, and kept dividing when the SAC was inhibited, resulting in the accumulation of mitotic defects, and in unstable and less-fit karyotypes.

TL;DR: In this paper, the authors show that cancer cells might exploit aneuploidy-induced genome instability and the resulting gene copy-number changes to survive under conditions of selective pressure, such as chemotherapy.

TL;DR: It is shown that cancer cells might exploit aneuploidy-induced genome instability to survive under conditions of selective pressure, such as chemotherapy, and might explain why some chemotherapies fail to succeed.

TL;DR: In this paper , aneuploidy was induced in non-transformed RPE1-hTERT cells and derived multiple stable clones with various degrees of chromosome imbalances.

TL;DR: It is shown that cancer cells might exploit aneuploidy-induced genome instability to survive under conditions of selective pressure, such as chemotherapy, and might explain why some chemotherapies fail to succeed.