H
Heidi L.H. Malaby
Researcher at University of Vermont
Publications - 13
Citations - 354
Heidi L.H. Malaby is an academic researcher from University of Vermont. The author has contributed to research in topics: Mitosis & Microtubule. The author has an hindex of 7, co-authored 13 publications receiving 185 citations. Previous affiliations of Heidi L.H. Malaby include University of Massachusetts Medical School.
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Journal ArticleDOI
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition
Yael Cohen-Sharir,James M. McFarland,Mai Abdusamad,Carolyn Marquis,Sara Vanessa Bernhard,Mariya Kazachkova,Helen Tang,Marica Rosaria Ippolito,Kathrin Laue,Johanna Zerbib,Heidi L.H. Malaby,Andrew Jones,Lisa-Marie Stautmeister,Irena Bockaj,René Wardenaar,Nicholas J. Lyons,Ankur K. Nagaraja,Ankur K. Nagaraja,Adam J. Bass,Adam J. Bass,Diana C.J. Spierings,Floris Foijer,Rameen Beroukhim,Rameen Beroukhim,Stefano Santaguida,Stefano Santaguida,Todd R. Golub,Todd R. Golub,Jason Stumpff,Zuzana Storchova,Uri Ben-David +30 more
TL;DR: In this paper, aneuploid cancer cells exhibited aberrant spindle geometry and dynamics, and kept dividing when the SAC was inhibited, resulting in the accumulation of mitotic defects, and in unstable and less-fit karyotypes.
Journal ArticleDOI
Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase.
Cindy L. Fonseca,Heidi L.H. Malaby,Leslie A. Sepaniac,Whitney Martin,Candice Byers,Anne Czechanski,Dana Messinger,Mary Tang,Ryoma Ohi,Ryoma Ohi,Laura G. Reinholdt,Jason Stumpff +11 more
TL;DR: These studies support a model in which the alignment of mitotic chromosomes promotes proper organization of chromosomes into a single nucleus and continued proliferation by ensuring that chromosomes segregate as a compact mass during anaphase.
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Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer
Kirsten Tracy,Coralee E. Tye,Prachi N. Ghule,Heidi L.H. Malaby,Jason Stumpff,Janet L. Stein,Gary S. Stein,Jane B. Lian +7 more
TL;DR: A role is revealed for the novel lncRNA, MANCR, in genomic stability of aggressive breast cancer, and it is identified as a potential therapeutic target.
Journal ArticleDOI
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Carolyn Marquis,Cindy L. Fonseca,Katelyn A. Queen,Lisa Wood,Sarah E. Vandal,Heidi L.H. Malaby,Joseph E. Clayton,Jason Stumpff +7 more
TL;DR: In this article, a subset of kinesin motor proteins involved in mitotic spindle control was inhibited, and the effect of the inhibition on the spindle microtubule dynamics was investigated.
Journal ArticleDOI
The Middle X Residue Influences Cotranslational N-Glycosylation Consensus Site Skipping
TL;DR: It is determined that NXS consensus sites containing large hydrophobic and negatively charged middle residues are frequently skipped by STT3A during protein translation, and a strong correlation between cotranslational N-glycosylation efficiency and the rate of post-translational EMT was determined.